Inhibition of toll-like receptor 4 activation by apigenin and chrysin via competition for sites and conformational changes
S Xiao, P Zhang, G Zhang, W Li, H Lin, X Hu - International Journal of …, 2023 - Elsevier
The activation of toll-like receptor 4 (TLR4) signaling is crucial for initiating and coordinating
the immune response against infections, and is proved as a vital target for inflammatory …
the immune response against infections, and is proved as a vital target for inflammatory …
Modeling and monitoring the effects of three partly conserved Ile residues in the dimerization domain of a Mip-like virulence factor from Escherichia coli
S Seal, T Chakraborty, S Polley, D Paul… - Journal of …, 2024 - Taylor & Francis
FKBP22, an Escherichia coli-made peptidyl-prolyl cis-trans isomerase, has shown
considerable homology with Mip-like virulence factors. While the C-terminal domain of this …
considerable homology with Mip-like virulence factors. While the C-terminal domain of this …
A conserved arginine residue in a staphylococcal anti-sigma factor is required to preserve its kinase activity, structure, and stability
RsbW, σB, and RsbV, encoded by Staphylococcus aureus and related bacteria, act as an
anti-sigma factor, an sigma factor, and an anti-anti-sigma factor, respectively. The interaction …
anti-sigma factor, an sigma factor, and an anti-anti-sigma factor, respectively. The interaction …
A staphylococcal cyclophilin carries a single domain and unfolds via the formation of an intermediate that preserves cyclosporin A binding activity
S Seal, S Polley, S Sau - Plos one, 2019 - journals.plos.org
Cyclophilin (Cyp), a peptidyl-prolyl cis-trans isomerase (PPIase), acts as a virulence factor in
many bacteria including Staphylococcus aureus. The enzymatic activity of Cyp is inhibited …
many bacteria including Staphylococcus aureus. The enzymatic activity of Cyp is inhibited …
Serine 106 preserves the tertiary structure, function, and stability of a cyclophilin from Staphylococcus aureus
S Seal, N Banerjee, R Mahato, T Kundu… - Journal of …, 2023 - Taylor & Francis
SaCyp, a staphylococcal cyclophilin involved in both protein folding and pathogenesis, has
a Ser residue at position 106 and a Trp residue at position 136. While Ser 106 of SaCyp …
a Ser residue at position 106 and a Trp residue at position 136. While Ser 106 of SaCyp …
Structurally distinct unfolding intermediates formed from a staphylococcal capsule-producing enzyme retained NADPH binding activity
CapF, a capsule-producing enzyme expressed by Staphylococcus aureus, binds NADPH
and exists as a dimer in the aqueous solution. Many other capsule-producing virulent …
and exists as a dimer in the aqueous solution. Many other capsule-producing virulent …
Alternative Sigma Factor of Staphylococcus aureus Interacts with the Cognate Antisigma Factor Primarily Using Its Domain 3
σB, an alternative sigma factor, is usually employed to tackle the general stress response in
Staphylococcus aureus and other Gram-positive bacteria. This protein, involved in S. aureus …
Staphylococcus aureus and other Gram-positive bacteria. This protein, involved in S. aureus …
Removal of an atypical region from a staphylococcal cyclophilin affects its structure, function, stability, and shape
SaCyp, a cyclophilin having 197 amino acid residues, acts both as a protein-folding catalyst
and a virulence factor in Staphylococcus aureus. Interestingly, a region, homologous to the …
and a virulence factor in Staphylococcus aureus. Interestingly, a region, homologous to the …