Orphan G protein coupled receptors in affective disorders
LR Watkins, C Orlandi - Genes, 2020 - mdpi.com
G protein coupled receptors (GPCRs) are the main mediators of signal transduction in the
central nervous system. Therefore, it is not surprising that many GPCRs have long been …
central nervous system. Therefore, it is not surprising that many GPCRs have long been …
Novel molecular targets of antidepressants
M Jarończyk, J Walory - Molecules, 2022 - mdpi.com
Antidepressants target a variety of proteins in the central nervous system (CNS), the most
important belonging to the family of G-protein coupled receptors and the family of …
important belonging to the family of G-protein coupled receptors and the family of …
Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR
Glycine is a major neurotransmitter involved in several fundamental neuronal processes.
The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine …
The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine …
Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders
The G protein alpha subunit o (Gαo) is one of the most abundant proteins in the nervous
system, and pathogenic mutations in its gene (GNAO1) cause movement disorder. However …
system, and pathogenic mutations in its gene (GNAO1) cause movement disorder. However …
Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex
GPR158 is an orphan G protein–coupled receptor (GPCR) highly expressed in the brain,
where it controls synapse formation and function. GPR158 has also been implicated in …
where it controls synapse formation and function. GPR158 has also been implicated in …
Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5
E Jeong, Y Kim, J Jeong, Y Cho - Nature communications, 2021 - nature.com
GPR158, a class C orphan GPCR, functions in cognition, stress-induced mood control, and
synaptic development. Among class C GPCRs, GPR158 is unique as it lacks a Venus flytrap …
synaptic development. Among class C GPCRs, GPR158 is unique as it lacks a Venus flytrap …
In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity
LR Watkins, C Orlandi - British Journal of Pharmacology, 2021 - Wiley Online Library
Background and Purpose Members of the GPCR family are targeted by a significant fraction
of the available FDA‐approved drugs. However, the physiological role and pharmacological …
of the available FDA‐approved drugs. However, the physiological role and pharmacological …
Beyond the ligand: Extracellular and transcellular G protein–coupled receptor complexes in physiology and pharmacology
G protein–coupled receptors (GPCRs) remain one of the most successful targets of US Food
and Drug Administration–approved drugs. GPCR research has predominantly focused on …
and Drug Administration–approved drugs. GPCR research has predominantly focused on …
Non-ceruloplasmin copper identifies a subtype of Alzheimer's disease (CuAD): Characterization of the cognitive profile and case of a CuAD patient carrying an RGS7 …
Alzheimer's disease (AD) is a type of dementia whose cause is incompletely defined.
Copper (Cu) involvement in AD etiology was confirmed by a meta-analysis on about 6000 …
Copper (Cu) involvement in AD etiology was confirmed by a meta-analysis on about 6000 …
Expression mapping and functional analysis of orphan G-protein-coupled receptor GPR158 in the adult mouse brain using a GPR158 transgenic mouse
J Chang, Z Song, S Wei, Y Zhou, J Ju, P Yao, Y Jiang… - Biomolecules, 2023 - mdpi.com
Aberrant expression of G-protein-coupled receptor 158 (GPR158) has been reported to be
inextricably linked to a variety of diseases affecting the central nervous system, including …
inextricably linked to a variety of diseases affecting the central nervous system, including …