Colorectal cancer is the third most common cancer worldwide with a high mortality rate at
the advanced stages. However, colorectal cancer is not a single type of tumor; its …

The liver is a key, frontline immune tissue. Ideally positioned to detect pathogens entering
the body via the gut, the liver appears designed to detect, capture, and clear bacteria …

This paper introduces a new bio-inspired optimization algorithm named the Liver Cancer
Algorithm (LCA), which mimics the liver tumor growth and takeover process. It uses an …

Colorectal cancer (CRC) is a predominant life‐threatening cancer, with liver and peritoneal
metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor …

Both the timing and molecular determinants of metastasis are unknown, hindering treatment
and prevention efforts. Here we characterize the evolutionary dynamics of this lethal process …

Colorectal cancer (CRC) is the third most common cancer type, and third highest in mortality
rates among cancer-related deaths in the United States. Originating from intestinal epithelial …

Awareness that traditional two-dimensional (2D) in vitro and nonrepresentative animal
models may not completely emulate the 3D hierarchical complexity of tissues and organs is …

Organs of future metastasis are not passive receivers of circulating tumor cells, but are
instead selectively and actively modified by the primary tumor before metastatic spread has …

Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC
count may not be the “best” indicator of metastatic risk because their heterogeneity is …

Metastasis is the primary cause of cancer-related mortality in colorectal cancer (CRC)
patients. How to improve therapeutic options for patients with metastatic CRC is the core …