Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon,
inevitable in kidney transplantation and one of the most important mechanisms for non-or …

The mTOR pathway has a central role in the regulation of cell metabolism, growth and
proliferation. Studies involving selective gene targeting of mTOR complexes (mTORC1 and …

Immunological memory specific to previously encountered antigens is a cardinal feature of
adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory …

All causes of renal allograft injury, when severe and/or sustained, can result in chronic
histological damage of which interstitial fibrosis and tubular atrophy are dominant features …

Background Tertiary lymphoid tissues (TLTs) are ectopic lymphoid tissues found in
chronically inflamed organs. Although studies have documented TLT formation in …

The pathogenesis of allograft (dys) function has been increasingly studied using 'omics'-
based technologies, but the focus on individual organs has created knowledge gaps that …

Inflammation impairs renal allograft survival but is difficult to quantify by eye at low densities.
Here we measured leukocyte abundance in early surveillance biopsies by digital image …

Innate recognition of microbial products and danger molecules by monocytes and
macrophages has been well established; this is mediated primarily by pattern-recognition …

Acute rejection of human allografts has been viewed mostly through the lens of adaptive
immunity, and the intragraft landscape of innate immunity genes has not been characterized …

Background The healthy kidney contains an extensive population of renal mononuclear
phagocytes (RMPs), with substantial phenotypic and functional diversity. However, how this …