COVID‐19 in children. II: Pathogenesis, disease spectrum and management

AR Howard‐Jones, DP Burgner… - … of paediatrics and …, 2022 - Wiley Online Library
The global disruption of the COVID‐19 pandemic has impacted the life of every child either
directly or indirectly. This review explores the pathophysiology, immune response, clinical …

Coronavirus infection and cholesterol metabolism

J Dai, H Wang, Y Liao, L Tan, Y Sun, C Song… - Frontiers in …, 2022 - frontiersin.org
Host cholesterol metabolism remodeling is significantly associated with the spread of human
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …

How the coronavirus infects cells—and why Delta is so dangerous

M Scudellari - 2021 - covid19.sld.cu
How the coronavirus infects cells — and why Delta is so dangerous Skip to main content
Thank you for visiting nature.com. You are using a browser version with limited support for …

Enhanced binding of the N501Y‐mutated SARS‐CoV‐2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations

B Luan, H Wang, T Huynh - FEBS letters, 2021 - Wiley Online Library
Recently, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants (B. 1.1.
7 and B. 1351) have emerged harbouring mutations that make them highly contagious. The …

Key interacting residues between RBD of SARS-CoV-2 and ACE2 receptor: combination of molecular dynamics simulation and density functional calculation

B Jawad, P Adhikari, R Podgornik… - Journal of chemical …, 2021 - ACS Publications
The spike protein of SARS-CoV-2 binds to the ACE2 receptor via its receptor-binding
domain (RBD), with the RBD–ACE2 complex presenting an essential molecular target for …

Remdesivir strongly binds to both RNA-dependent RNA polymerase and main protease of SARS-CoV-2: Evidence from molecular simulations

HL Nguyen, NQ Thai, DT Truong… - The Journal of Physical …, 2020 - ACS Publications
The outbreak of a new coronavirus SARS-CoV-2 (severe acute respiratory syndrome–
coronavirus 2) has caused a global COVID-19 (coronavirus disease 2019) pandemic …

Molecular basis of SARS-CoV-2 infection and rational design of potential antiviral agents: modeling and simulation approaches

A Frances-Monerris, C Hognon, T Miclot… - Journal of Proteome …, 2020 - ACS Publications
The emergence in late 2019 of the coronavirus SARS-CoV-2 has resulted in the
breakthrough of the COVID-19 pandemic that is presently affecting a growing number of …

Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

Electrostatic features for the receptor binding domain of SARS-COV-2 wildtype and its variants. Compass to the severity of the future variants with the charge-rule

FL Barroso da Silva, CC Giron… - The Journal of Physical …, 2022 - ACS Publications
Electrostatic intermolecular interactions are important in many aspects of biology. We have
studied the main electrostatic features involved in the interaction of the receptor-binding …

Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation

H Nguyen, HL Nguyen, PD Lan, NQ Thai… - Chemical Society …, 2023 - pubs.rsc.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …