The tumor microenvironment (TME) is comprised of many different cell populations, such as
cancer-associated fibroblasts and various infiltrating immune cells, and non-cell …

Epithelial to mesenchymal transition (EMT) contributes to tumor progression, cancer cell
invasion, and therapy resistance. EMT is regulated by transcription factors such as the …

Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal
squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival …

The Trk family of receptors play a wide variety of roles in physiological and disease
processes in both neuronal and non-neuronal tissues. Amongst these the TrkB receptor in …

Epithelial to mesenchymal transition (EMT) is a dynamic cellular process that is essential for
the development of metastatic disease. During EMT, a tumor cell with epithelial …

Twist, the basic helix-loop-helix transcription factor, is involved in the process of epithelial to
mesenchymal transitions (EMTs), which play an essential role in cancer metastasis …

EGFR is a potent stimulator of invasion and metastasis in head and neck squamous cell
carcinomas (HNSCC). However, the mechanism by which EGFR may stimulate tumor cell …

Background: Head and neck squamous cell carcinoma (HNSCC) is the seventh most
common type of cancer worldwide. Its highly aggressive and heterogeneous nature and …

Small cell lung cancer (SCLC) is an extremely aggressive neuroendocrine tumor,
accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid …

Perineural invasion (PNI) is a mechanism of tumor dissemination that can provide a
challenge to tumor eradication and that is correlated with poor survival. Squamous cell …