[HTML][HTML] Synthetic bacterial therapies for intestinal diseases based on quorum-sensing circuits
Z Dang, M Gao, L Wang, J Wu, Y Guo, Z Zhu… - Biotechnology …, 2023 - Elsevier
Bacterial therapy has become a key strategy against intestinal infectious diseases in recent
years. Moreover, regulating the gut microbiota through traditional fecal microbiota …
years. Moreover, regulating the gut microbiota through traditional fecal microbiota …
Automated model-predictive design of synthetic promoters to control transcriptional profiles in bacteria
Transcription rates are regulated by the interactions between RNA polymerase, sigma factor,
and promoter DNA sequences in bacteria. However, it remains unclear how non-canonical …
and promoter DNA sequences in bacteria. However, it remains unclear how non-canonical …
Synthetic biological circuits within an orthogonal central dogma
A Costello, AH Badran - Trends in biotechnology, 2021 - cell.com
Synthetic biology strives to reliably control cellular behavior, typically in the form of user-
designed interactions of biological components to produce a predetermined output …
designed interactions of biological components to produce a predetermined output …
An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
Synthetic biology has the potential to bring forth advanced genetic devices for applications
in healthcare and biotechnology. However, accurately predicting the behavior of engineered …
in healthcare and biotechnology. However, accurately predicting the behavior of engineered …
Universal structural requirements for maximal robust perfect adaptation in biomolecular networks
A Gupta, M Khammash - Proceedings of the National …, 2022 - National Acad Sciences
Adaptation is a running theme in biology. It allows a living system to survive and thrive in the
face of unpredictable environments by maintaining key physiological variables at their …
face of unpredictable environments by maintaining key physiological variables at their …
Biological materials: the next frontier for cell-free synthetic biology
Advancements in cell-free synthetic biology are enabling innovations in sustainable
biomanufacturing, that may ultimately shift the global manufacturing paradigm toward …
biomanufacturing, that may ultimately shift the global manufacturing paradigm toward …
[HTML][HTML] Context-dependent redesign of robust synthetic gene circuits
Cells provide dynamic platforms for executing exogenous genetic programs in synthetic
biology, resulting in highly context-dependent circuit performance. Recent years have seen …
biology, resulting in highly context-dependent circuit performance. Recent years have seen …
Enhancing circuit stability under growth feedback with supplementary repressive regulation
The field of synthetic biology and biosystems engineering increasingly acknowledges the
need for a holistic design approach that incorporates circuit-host interactions into the design …
need for a holistic design approach that incorporates circuit-host interactions into the design …
[HTML][HTML] CRISPR/Cas9 in the era of nanomedicine and synthetic biology
TJN Schmidt, B Berarducci, S Konstantinidou… - Drug discovery today, 2023 - Elsevier
The CRISPR/Cas system was first discovered as a defense mechanism in bacteria and is
now used as a tool for precise gene-editing applications. Rapidly evolving, it is increasingly …
now used as a tool for precise gene-editing applications. Rapidly evolving, it is increasingly …
Control engineering and synthetic biology: working in synergy for the analysis and control of microbial systems
Highlights•Control engineering enables rigorous analysis and design of microbial
systems.•Feedback control is essential to the design of robust and reliable biological …
systems.•Feedback control is essential to the design of robust and reliable biological …