Diosgenin: an updated pharmacological review and therapeutic perspectives

P Semwal, S Painuli, T Abu-Izneid… - Oxidative medicine …, 2022 - Wiley Online Library
Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain
a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high …

[HTML][HTML] Bioactive compounds from Polygonatum genus as anti-diabetic agents with future perspectives

Y Shi, D Si, D Chen, X Zhang, Z Han, Q Yu, J Liu, J Si - Food chemistry, 2023 - Elsevier
Diabetes mellitus (DM) is one of the most serious health problems worldwide. Species in the
genus Polygonatum are traditional food and medicinal plants, which play an important role …

Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases

X Li, S Liu, L Qu, Y Chen, C Yuan, A Qin, J Liang… - Journal of …, 2021 - Elsevier
Background and ethnopharmacological relevance Dioscin and diosgenin derived from
plants of the genus Dioscoreaceae such as D. nipponica and D. panthaica Prain et Burk …

Diosgenin: An ingress towards solving puzzle for diabetes treatment

P Arya, P Kumar - Journal of Food Biochemistry, 2022 - Wiley Online Library
The consumption and composition of food in daily life predict our health in long run. The
relation of diabetes to sweets is quite popular. Diabetes hampers the glucose and insulin …

Zebrafish: A new promise to study the impact of metabolic disorders on the brain

B Ghaddar, N Diotel - International Journal of Molecular Sciences, 2022 - mdpi.com
Zebrafish has become a popular model to study many physiological and pathophysiological
processes in humans. In recent years, it has rapidly emerged in the study of metabolic …

Diosgenin suppresses COX-2 and mPGES-1 via GR and improves LPS-induced liver injury in mouse

I Tsukayama, T Mega, N Hojo, K Toda… - Prostaglandins & other …, 2021 - Elsevier
Using a wild yam (Dioscorea japonica), we previously found novel anti-inflammatory and
anti-carcinogenic effects via the downregulation of cyclooxygenase (COX)-2 and …

Microfiltered red‐purple pitaya concentrate: A promising multifunctional food‐derived colorant

FT de Sousa Silva, JD da Rocha Viana… - Journal of Food …, 2024 - Wiley Online Library
Red pitaya fruit has become a source of natural colorant, because it is rich in betalains, a
pigment that imparts a red‐purple color that interests the food and cosmetics industries. This …

An Association between Insulin Resistance and Neurodegeneration in Zebrafish Larval Model (Danio rerio)

NN Md Razip, S Mohd Noor, A Norazit… - International Journal of …, 2022 - mdpi.com
Background: Type 2 diabetes mellitus has recently been identified as a mediator of
neurodegeneration. However, the molecular mechanisms have not been clearly elucidated …

[HTML][HTML] Exploring the therapeutic potential of dioscin and diosgenin in neurological disorders

S Biswas, P Patil, S Ranjan, A Gautam - Brain Behavior and Immunity …, 2024 - Elsevier
This comprehensive review delves into the potential therapeutic efficacy of dioscin and
diosgenin, phytocompounds extracted from the Dioscoreaceae family, in alleviating …

Glucose inhibits haemostasis and accelerates diet-induced hyperlipidaemia in zebrafish larvae

S Morris, PM Cholan, WJ Britton, SH Oehlers - Scientific Reports, 2021 - nature.com
Hyperglycaemia damages the microvasculature in part through the reduced recruitment of
immune cells and interference with platelet signalling, leading to poor wound healing and …