CD8+ T cells are involved in the pathogenesis of inflammatory bowel disease (IBD), a
complex multifactorial chronic disease. Here, we present an overview of the current research …

Regulatory T cells (Treg) are essential to maintain immune homeostasis and prevent
autoimmune disorders. While the function and molecular regulation of Foxp3+ CD4+ Tregs …

Immunomodulation holds therapeutic promise against brain injuries, but leveraging this
approach requires a precise understanding of mechanisms. We report that CD8+ CD122+ …

Regulatory T cells (Tregs) play a key role in the peripheral self‐tolerance and preventing
autoimmunity. While classical CD4+ Foxp3+ Tregs are well established, their CD8+ …

The vast majority of studies regarding the immune basis of MS (and its animal model, EAE)
have largely focused on CD4+ T-cells as mediators and regulators of disease. Interestingly …

Although selective IgM deficiency (SIGMD) was described almost five decades ago, it was
largely ignored as a primary immunodeficiency. SIGMD is defined as serum IgM levels …

Regulatory T-cells (Treg) are critical for the maintenance of immune homeostasis and
tolerance induction. While the immunosuppressive mechanisms of Treg have been …

ABSTRACT CD4+ Foxp3+ regulatory T cells (Tregs) in the tumor microenvironment restrain
antitumor immunity, resulting in tumor aggression and poor survival in hepatocellular …

The immune system is regulated by distinct signaling pathways that control the development
and function of the immune cells. Accumulating evidence suggest that ligation of aryl …

The Fas/FasL (CD95/CD178) system is required for immune regulation; however, it is
unclear in which cells, when, and where Fas/FasL molecules act in the immune system. We …