The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with
their receptor proteins rule fundamental processes in cell biology. One of the …

Background The most demanding challenge in research on molecular aspects within the
flow of biological information is posed by the complex carbohydrates (glycan part of cellular …

Glycan–protein interactions are of utmost importance in several biological phenomena.
Although the variety of carbohydrate residues in mammalian cells is limited to less than a …

Much effort has been made during the last decade to design lectin inhibitors as therapeutics
against viral and bacterial adhesion or to control biological functions. The chemical strategy …

Carbohydrates present a special set of challenges to the generation of force fields. First, the
tertiary structures of monosaccharides are complex merely by virtue of their exceptionally …

Glycan recognition by sugar receptors (lectins) is intimately involved in many aspects of cell
physiology. However, the factors explaining the exquisite selectivity of their functional …

Coding of biological information is not confined to nucleic acids and proteins. Endowed with
the highest level of structural versatility among biomolecules, the glycan chains of cellular …

Human tandem-repeat-type galectin-9 is a potent adhesion/growth-regulatory effector via
lectin capacity of its N-and C-terminal domains. This bioactivity prompted further …

The emerging functional versatility of cellular glycans makes research on the design of
synthetic inhibitors a timely topic. In detail, the combination of ligand (or headgroup or …

Glycan recognition by lectins initiates clinically relevant processes such as toxin binding or
tumor spread. Thus, the development of potent inhibitors has a medical perspective. Toward …