Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …

A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of
toxicological hazard information for most compounds. Therefore, new approaches are being …

Micro-electrode arrays (MEAs) are increasingly used to characterize neuronal network
activity of human induced pluripotent stem cell (hiPSC)-derived neurons. Despite their gain …

Currently, the identification of chemicals that have the potential to induce developmental
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …

Predicting human safety risks of novel xenobiotics remains a major challenge, partly due to
the limited availability of human cells to evaluate tissue-specific toxicity. Recent progress in …

Real-time stimulation and recording of neural cell bioelectrical activity could provide an
unprecedented insight in understanding the functions of the nervous system, and it is crucial …

Due to their toxicity and persistence in the environment, brominated flame retardants (BFRs)
are being phased out of commercial use, leading to the increased use of alternative …

Microelectrode array (MEA) approaches have been proposed as a tool for detecting
functional changes in electrically excitable cells, including neurons, exposed to drugs …

Drug-induced seizure liabilities produce significant compound attrition during drug
discovery. Currently available in vitro cytotoxicity assays cannot predict all toxicity …

NMDA receptors play crucial roles in excitatory synaptic transmission. Rare variants in
GRIN2A encoding the GluN2A subunit are associated with a spectrum of disorders, ranging …