Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

Abstract We analyzed transcriptomes (n= 211), whole exomes (n= 99) and targeted exomes
(n= 103) from 216 malignant pleural mesothelioma (MPM) tumors. Using RNA-seq data, we …

Prostate cancer represents a substantial clinical challenge because it is difficult to predict
outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 …

Although autophagy controls cell death and survival, underlying mechanisms are poorly
understood, and it is unknown whether autophagy affects only whether or not cells die or …

Metastatic prostate cancer is characterized by recurrent genomic copy number alterations
that are presumed to contribute to resistance to hormone therapy. We identified CHD1 loss …

Synthetic lethality and collateral lethality are two well-validated conceptual strategies for
identifying therapeutic targets in cancers with tumour-suppressor gene deletions,,. Here, we …

Castration-resistant prostate cancer (CRPC) is associated with a poor prognosis and poses
considerable therapeutic challenges. Recent genetic and technological advances have …

Purpose: Neuroendocrine prostate cancer (NEPC) is an aggressive form of castration-
resistant prostate cancer (CRPC) for which effective therapies are lacking. We previously …