The vasodilatory properties of nitric oxide (NO) have been utilized in pharmacotherapy for
more than 130 years. Still today, NO‐donor drugs are important in the management of …

The gaseous XO molecules (X= C, N or O) bind to the heme prosthetic group of heme
proteins, and thereby activate or inhibit key biological processes. These events depend on …

In exponentially growing yeast, the heme enzyme, cytochrome c peroxidase (Ccp1) is
targeted to the mitochondrial intermembrane space. When the fermentable source (glucose) …

This review summarizes our current understanding of the geometric and electronic
structures of ferrous and ferric heme–nitrosyls, which are of key importance for the biological …

The chemical synthesis of the 184‐residue ferric heme‐binding protein nitrophorin 4 was
accomplished by sequential couplings of five unprotected peptide segments using α …

Nitrite is an important metabolite in the physiological pathways of NO and other nitrogen
oxides in both enzymatic and nonenzymatic reactions. The ferric heme b protein nitrophorin …

Heme sensor proteins are present in organisms ranging from bacteria to mammals, typically
consisting of a catalytic domain and a heme‐containing sensor domain, which can bind …

Nitrophorins represent a unique class of heme proteins that are able to perform the delicate
transportation and release of the free-radical gaseous messenger nitric oxide (NO) in a pH …

In this work, we present a study of the influence of the protein matrix on its ability to tune the
binding of small ligands such as NO, cyanide (CN–), and histamine to the ferric heme iron …

NO is an important signaling molecule in human tissue. However, the mechanisms by which
this molecule is controlled and directed are currently little understood. Nitrophorins (NPs) …