The development of functional non-viral vectors for gene delivery

S Patil, YG Gao, X Lin, Y Li, K Dang, Y Tian… - International journal of …, 2019 - mdpi.com
Gene therapy is manipulation in/of gene expression in specific cells/tissue to treat diseases.
This manipulation is carried out by introducing exogenous nucleic acids, such as DNA or …

Cancer‐targeting nanoparticles for combinatorial nucleic acid delivery

HJ Vaughan, JJ Green, SY Tzeng - Advanced Materials, 2020 - Wiley Online Library
Nucleic acids are a promising type of therapeutic for the treatment of a wide range of
conditions, including cancer, but they also pose many delivery challenges. For efficient and …

Biodegradable polymers for gene delivery

TJ Thomas, HA Tajmir-Riahi, CKS Pillai - Molecules, 2019 - mdpi.com
The cellular transport process of DNA is hampered by cell membrane barriers, and hence, a
delivery vehicle is essential for realizing the potential benefits of gene therapy to combat a …

Poloxamers, poloxamines and polymeric micelles: Definition, structure and therapeutic applications in cancer

M Almeida, M Magalhães, F Veiga… - Journal of Polymer …, 2018 - Springer
Research for new therapies to treat diseases like cancer, it is one of the focus of Health
Sciences. Nowadays, the available therapeutic strategies have in many cases limitations …

Non-viral gene delivery systems for tissue repair and regeneration

P Wu, H Chen, R Jin, T Weng, JK Ho, C You… - Journal of translational …, 2018 - Springer
Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery.
The ideal treatment for such tissue loss is autografting, but donor sites are often limited …

Multifunctional polymeric micellar nanomedicine in the diagnosis and treatment of cancer

N Raval, R Maheshwari, H Shukla, K Kalia… - Materials Science and …, 2021 - Elsevier
Polymeric micelles are a prevalent topic of research for the past decade, especially
concerning their fitting ability to deliver drug and diagnostic agents. This delivery system …

Multifunctional polymeric micelle-based nucleic acid delivery: Current advances and future perspectives

I Jarak, M Pereira-Silva, AC Santos, F Veiga… - Applied Materials …, 2021 - Elsevier
Nucleic acid (NA) therapeutics are a rapidly growing class of biomedicines with the ability to
manipulate gene expression in potent and specific manner, and with the enormous potential …

A summary on non-viral systems for gene delivery based on natural and synthetic polymers

R Sarvari, M Nouri, S Agbolaghi… - … Journal of Polymeric …, 2022 - Taylor & Francis
Gene delivery systems necessitate the gene therapy, which is a unique approach for
applying the tunable genes to treat any diseases. To tackle down the disadvantages of viral …

Endosomal Escape of Bioactives Deployed via Nanocarriers: Insights Into the Design of Polymeric Micelles

AM Butt, N Abdullah, NNIM Rani, N Ahmad… - Pharmaceutical …, 2022 - Springer
Cytoplasmic delivery of bioactives requires the use of strategies such as active transport,
electroporation, or the use of nanocarriers such as polymeric nanoparticles, liposomes …

Delivery of therapeutic miRNA using polymer-based formulation

E Ban, TH Kwon, A Kim - Drug delivery and translational research, 2019 - Springer
MicroRNAs (miRNAs) are short non-coding RNAs that play important roles in many cellular
processes such as development, proliferation, differentiation, and apoptosis. For this reason …