[HTML][HTML] Prolyl isomerases in gene transcription
SD Hanes - Biochimica et Biophysica Acta (BBA)-General Subjects, 2015 - Elsevier
Abstract Background Peptidyl-prolyl isomerases (PPIases) are enzymes that assist in the
folding of newly-synthesized proteins and regulate the stability, localization, and activity of …
folding of newly-synthesized proteins and regulate the stability, localization, and activity of …
The role of nuclear bodies in gene expression and disease
M Morimoto, CF Boerkoel - Biology, 2013 - mdpi.com
This review summarizes the current understanding of the role of nuclear bodies in regulating
gene expression. The compartmentalization of cellular processes, such as ribosome …
gene expression. The compartmentalization of cellular processes, such as ribosome …
Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
AH Brody, SH Nies, F Guan, LM Smith… - Molecular …, 2022 - Springer
Background Genetic variation at the PTK2B locus encoding the protein Pyk2 influences
Alzheimer's disease risk. Neurons express Pyk2 and the protein is required for Amyloid-β …
Alzheimer's disease risk. Neurons express Pyk2 and the protein is required for Amyloid-β …
Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection
The regulation of DNA double-strand break (DSB) repair by phosphorylation-dependent
signaling pathways is crucial for the maintenance of genome stability; however, remarkably …
signaling pathways is crucial for the maintenance of genome stability; however, remarkably …
Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial …
LN Glass, G Swapna, SS Chavadi… - PLoS …, 2017 - journals.plos.org
We have previously shown that the Mycobacterium tuberculosis universal stress protein
Rv2623 regulates mycobacterial growth and may be required for the establishment of …
Rv2623 regulates mycobacterial growth and may be required for the establishment of …
Recognition modes of RNA tetraloops and tetraloop‐like motifs by RNA‐binding proteins
R Thapar, AP Denmon… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
RNA hairpins are the most commonly occurring secondary structural elements in RNAs and
serve as nucleation sites for RNA folding, RNA–RNA, and RNA–protein interactions. RNA …
serve as nucleation sites for RNA folding, RNA–RNA, and RNA–protein interactions. RNA …
Structural basis for regulation of RNA-binding proteins by phosphorylation
R Thapar - ACS chemical biology, 2015 - ACS Publications
Ribonucleoprotein complexes involved in pre-mRNA splicing and mRNA decay are often
regulated by phosphorylation of RNA-binding proteins. Cells use phosphorylation …
regulated by phosphorylation of RNA-binding proteins. Cells use phosphorylation …
Intranuclear and higher‐order chromatin organization of the major histone gene cluster in breast cancer
Alterations in nuclear morphology are common in cancer progression. However, the degree
to which gross morphological abnormalities translate into compromised higher‐order …
to which gross morphological abnormalities translate into compromised higher‐order …
[HTML][HTML] Roles of prolyl isomerases in RNA-mediated gene expression
R Thapar - Biomolecules, 2015 - mdpi.com
The peptidyl-prolyl cis-trans isomerases (PPIases) that include immunophilins (cyclophilins
and FKBPs) and parvulins (Pin1, Par14, Par17) participate in cell signaling, transcription …
and FKBPs) and parvulins (Pin1, Par14, Par17) participate in cell signaling, transcription …
Oncogenic hijacking of the PIN1 signaling network
Cellular choices are determined by developmental and environmental stimuli through
integrated signal transduction pathways. These critically depend on attainment of proper …
integrated signal transduction pathways. These critically depend on attainment of proper …