Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Epigenetic age prediction
DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice
Partial reprogramming by expression of reprogramming factors (Oct4, Sox2, Klf4 and c-Myc)
for short periods of time restores a youthful epigenetic signature to aging cells and extends …
for short periods of time restores a youthful epigenetic signature to aging cells and extends …
Biological age is increased by stress and restored upon recovery
Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …
Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice
J Sanz-Ros, N Romero-García, C Mas-Bargues… - Science …, 2022 - science.org
Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to
delay the degenerative changes associated with aging and frailty are particularly interesting …
delay the degenerative changes associated with aging and frailty are particularly interesting …
Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation
Heterochronic parabiosis (HPB) is known for its functional rejuvenation effects across
several mouse tissues. However, its impact on biological age and long-term health is …
several mouse tissues. However, its impact on biological age and long-term health is …
DNA methylation predicts age and provides insight into exceptional longevity of bats
Exceptionally long-lived species, including many bats, rarely show overt signs of aging,
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …
Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice
Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance
and possibly to the longevity of the longest-lived rodent—the naked mole-rat,. To study …
and possibly to the longevity of the longest-lived rodent—the naked mole-rat,. To study …
Universal DNA methylation age across mammalian tissues
Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …
DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse
We have developed a mouse DNA methylation array that contains 296,070 probes
representing the diversity of mouse DNA methylation biology. We present a mouse …
representing the diversity of mouse DNA methylation biology. We present a mouse …