Developmental consequences of fetal exposure to drugs: what we know and what we still must learn

EJ Ross, DL Graham, KM Money… - …, 2015 - nature.com
Most drugs of abuse easily cross the placenta and can affect fetal brain development. In
utero exposures to drugs thus can have long-lasting implications for brain structure and …

Mechanisms of action and persistent neuroplasticity by drugs of abuse

ER Korpi, B den Hollander, U Farooq… - Pharmacological …, 2015 - Elsevier
Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: Insights from rodent models

K Marquardt, JL Brigman - Alcohol, 2016 - Elsevier
Abstract Fetal Alcohol Spectrum Disorders (FASD) are characterized by deficits in working
memory, response inhibition, and behavioral flexibility. However, the combination and …

Acute and chronic effects of ethanol on learning-related synaptic plasticity

CF Zorumski, S Mennerick, Y Izumi - Alcohol, 2014 - Elsevier
Alcoholism is associated with acute and long-term cognitive dysfunction including memory
impairment, resulting in substantial disability and cost to society. Thus, understanding how …

Association of maternal exposure to childhood abuse with elevated risk for autism in offspring

AL Roberts, K Lyall, JW Rich-Edwards… - JAMA …, 2013 - jamanetwork.com
Importance Adverse perinatal circumstances have been associated with increased risk for
autism in offspring. Women exposed to childhood abuse experience more adverse perinatal …

Prenatal influences on temperament development: The role of environmental epigenetics

MA Gartstein, MK Skinner - Development and Psychopathology, 2018 - cambridge.org
This review summarizes current knowledge and outlines future directions relevant to
questions concerning environmental epigenetics and the processes that contribute to …

Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice

BI Laufer, K Mantha, ML Kleiber… - Disease models & …, 2013 - journals.biologists.com
Fetal alcohol spectrum disorders (FASDs) are characterized by life-long changes in gene
expression, neurodevelopment and behavior. What mechanisms initiate and maintain these …

[HTML][HTML] The maternal-placental-fetal interface: Adaptations of the HPA axis and immune mediators following maternal stress and prenatal alcohol exposure

C Ruffaner-Hanson, S Noor, MS Sun, E Solomon… - Experimental …, 2022 - Elsevier
This review addresses underlying physiological, cellular, and molecular factors that alter the
developing fetal brain stress circuits and responses of the hypothalamic-pituitary-adrenal …

The early developmental outcomes of prenatal alcohol exposure: A review

S Subramoney, E Eastman, C Adnams, DJ Stein… - Frontiers in …, 2018 - frontiersin.org
Aim: This paper systematically reviews the literature on the effects of prenatal alcohol
exposure on early child development from birth to 5 years with the aim to synthesize the …

Microglia and alcohol meet at the crossroads: Microglia as critical modulators of alcohol neurotoxicity

JF Henriques, CC Portugal, T Canedo, JB Relvas… - Toxicology letters, 2018 - Elsevier
Alcohol use disorders affect millions of people worldwide causing huge social and economic
burden on modern society. Excessive alcohol consumption or intoxication provokes severe …