Cracking the egg: potential of the developing chicken as a model system for nonclinical safety studies of pharmaceuticals

S Bjørnstad, LPE Austdal, B Roald, JC Glover… - … of Pharmacology and …, 2015 - ASPET
The advance of perinatal medicine has improved the survival of extremely premature
babies, thereby creating a new and heterogeneous patient group with limited information on …

Applications of gene editing in chickens: a new era is on the horizon

H Sid, B Schusser - Frontiers in genetics, 2018 - frontiersin.org
The chicken represents a valuable model for research in the area of immunology, infectious
diseases as well as developmental biology. Although it was the first livestock species to …

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells

D Iyer, L Gambardella, WG Bernard, F Serrano… - …, 2015 - journals.biologists.com
The epicardium has emerged as a multipotent cardiovascular progenitor source with
therapeutic potential for coronary smooth muscle cell, cardiac fibroblast (CF) and …

A novel human pluripotent stem cell-derived neural crest model of treacher collins syndrome shows defects in cell death and migration

F Serrano, WG Bernard, A Granata, D Iyer… - Stem Cells and …, 2019 - liebertpub.com
The neural crest (NC) is a transient multipotent cell population present during embryonic
development. The NC can give rise to multiple cell types and is involved in a number of …

Genetic resilience in chickens against bacterial, viral and protozoal pathogens

H Gul, G Habib, IM Khan, SU Rahman… - Frontiers in Veterinary …, 2022 - frontiersin.org
The genome contributes to the uniqueness of an individual breed, and enables distinctive
characteristics to be passed from one generation to the next. The allelic heterogeneity of a …

A new take on an old story: chick limb organ culture for skeletal niche development and regenerative medicine evaluation

EL Smith, JM Kanczler, ROC Oreffo - European cells & materials, 2013 - eprints.soton.ac.uk
Scientific research and progress, particularly in the drug discovery and regenerative
medicine fields, is typically dependent on suitable animal models to develop new and …

Ex vivo models simulating the bone marrow environment and predicting response to therapy in multiple myeloma

K Papadimitriou, IV Kostopoulos, A Tsopanidou… - Cancers, 2020 - mdpi.com
Multiple myeloma (MM) remains incurable despite the abundance of novel drugs. As it has
been previously shown, preclinical 2D models fail to predict disease progression due to their …

Characterization of immortalized dairy goat male germline stem cells (mGSCs)

H Zhu, J Ma, R Du, L Zheng, J Wu… - Journal of Cellular …, 2014 - Wiley Online Library
Male germline stem cells (mGSCs), in charge for the fertility in male testis, are the only kind
of adult stem cells that transmit genetic information to next generation, with promising …

Evaluation of intracellular labeling with micron-sized particles of iron oxide (MPIOs) as a general tool for in vitro and in vivo tracking of human stem and progenitor …

JL Boulland, DSY Leung, M Thuen… - Cell …, 2012 - journals.sagepub.com
Magnetic resonance imaging (MRI)-based tracking is increasingly attracting attention as a
means of better understanding stem cell dynamics in vivo. Intracellular labeling with …

Towards human organ generation using interspecies blastocyst complementation: Challenges and perspectives for therapy

H Sarmah, A Sawada, Y Hwang, A Miura… - Frontiers in Cell and …, 2023 - frontiersin.org
Millions of people suffer from end-stage refractory diseases. The ideal treatment option for
terminally ill patients is organ transplantation. However, donor organs are in absolute …