The Physiology of Enteric Glia

J Gonzales, BD Gulbransen - Annual Review of Physiology, 2024 - annualreviews.org
Enteric glia are the partners of neurons in the enteric nervous system throughout the
gastrointestinal tract. Roles fulfilled by enteric glia are diverse and contribute to maintaining …

Host Immune Responses to Clostridioides difficile: Toxins and Beyond

B Nibbering, DN Gerding, EJ Kuijper… - Frontiers in …, 2021 - frontiersin.org
Clostridioides difficile is often resistant to the actions of antibiotics to treat other bacterial
infections and the resulting C. difficile infection (CDI) is among the leading causes of …

The sympathetic nervous system drives hyperinflammatory responses to Clostridioides difficile infection

D Tyus, JL Leslie, F Naz, MJ Uddin, B Thompson… - Cell Reports …, 2024 - cell.com
Clostridioides difficile infection (CDI) is a leading cause of hospital-acquired infections in the
United States, known for triggering severe disease by hyperactivation of the host response …

From diversity to disease: unravelling the role of enteric glial cells

S Santhosh, L Zanoletti, LA Stamp, MM Hao… - Frontiers in …, 2024 - frontiersin.org
Enteric glial cells (EGCs) are an essential component of the enteric nervous system (ENS)
and play key roles in gastrointestinal development, homeostasis, and disease. Derived from …

Gut microbiota-related inflammation factors as a potential biomarker for diagnosing major depressive disorder

S Bai, H Bai, D Li, Q Zhong, J Xie… - Frontiers in cellular and …, 2022 - frontiersin.org
Objective Although many works have been done, the objectively measured diagnostic
biomarkers are not available. Thus, we conducted this study to identify potential biomarkers …

Inulin inhibits the inflammatory response through modulating enteric glial cell function in type 2 diabetic mellitus mice by reshaping intestinal flora

MY Li, JQ Duan, XH Wang, M Liu, QY Yang, Y Li… - ACS …, 2023 - ACS Publications
Inulin, a commonly used dietary fiber supplement, is capable of modulating the gut
microbiome. Chronic inflammation resulting from metabolic abnormalities and gut flora …

Role of Pannexin-1-P2X7R signaling on cell death and pro-inflammatory mediator expression induced by Clostridioides difficile toxins in enteric glia

AV Loureiro, LI Moura-Neto, CS Martins… - Frontiers in …, 2022 - frontiersin.org
Clostridioides difficile (C. difficile) produces toxins A (TcdA) and B (TcdB), both associated
with intestinal damage and diarrhea. Pannexin-1 (Panx1) channels allows the passage of …

Involvement of Abnormal P-α-Syn Accumulation and TLR2-Mediated Inflammation of Schwann Cells in Enteric Autonomic Nerve Dysfunction of Parkinson's Disease …

W Jiang, Y Cheng, Y Wang, J Wu, Z Rong, L Sun… - Molecular …, 2023 - Springer
The study was designed to investigate the pathogenesis of gastrointestinal (GI) impairment
in Parkinson's disease (PD). We utilized 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine …

Daidzein protects Caco-2 cells against lipopolysaccharide-induced intestinal epithelial barrier injury by suppressing PI3K/AKT and P38 pathways

B Zhang, X Wei, M Ding, Z Luo, X Tan, Z Zheng - Molecules, 2022 - mdpi.com
The intestinal epithelium provides an important barrier against bacterial endotoxin
translocation, which can regulate the absorption of water and ions. The disruption of …

S100B affects gut microbiota biodiversity

V Romano Spica, F Valeriani, M Orsini… - International Journal of …, 2023 - mdpi.com
This in vivo study in mice addresses the relationship between the biodiversity of the
microbiota and the levels of S100B, a protein present in enteroglial cells, but also in foods …