[HTML][HTML] Microglia polarization from M1 to M2 in neurodegenerative diseases

S Guo, H Wang, Y Yin - Frontiers in aging neuroscience, 2022 - frontiersin.org
Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases
such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis …

Microbial regulation of host physiology by short-chain fatty acids

B van der Hee, JM Wells - Trends in Microbiology, 2021 - cell.com
Our ancestral diet consisted of much more nondigestible fiber than that of many societies
today. Thus, from an evolutionary perspective the human genome and its physiological and …

[HTML][HTML] SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry

J Kee, S Thudium, DM Renner, K Glastad, K Palozola… - Nature, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of
2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID …

Auxin signaling: Research advances over the past 30 years

Z Yu, F Zhang, J Friml, Z Ding - Journal of Integrative Plant …, 2022 - Wiley Online Library
Auxin, one of the first identified and most widely studied phytohormones, has been and will
remain a hot topic in plant biology. After more than a century of passionate exploration, the …

Understanding plant stress memory response for abiotic stress resilience: Molecular insights and prospects

M Sharma, P Kumar, V Verma, R Sharma… - Plant Physiology and …, 2022 - Elsevier
As sessile species and without the possibility of escape, plants constantly face numerous
environmental stresses. To adapt in the external environmental cues, plants adjust …

scJoint integrates atlas-scale single-cell RNA-seq and ATAC-seq data with transfer learning

Y Lin, TY Wu, S Wan, JYH Yang, WH Wong… - Nature …, 2022 - nature.com
Single-cell multiomics data continues to grow at an unprecedented pace. Although several
methods have demonstrated promising results in integrating several data modalities from …

Cytoplasmic chromatin triggers inflammation in senescence and cancer

Z Dou, K Ghosh, MG Vizioli, J Zhu, P Sen… - Nature, 2017 - nature.com
Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and
silencing,,. However, we recently discovered the presence of cytoplasmic chromatin …

An epigenetic role of mitochondria in cancer

Y Liu, C Chen, X Wang, Y Sun, J Zhang, J Chen, Y Shi - Cells, 2022 - mdpi.com
Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Epigenetic regulation in plant abiotic stress responses

YN Chang, C Zhu, J Jiang, H Zhang… - Journal of integrative …, 2020 - Wiley Online Library
In eukaryotic cells, gene expression is greatly influenced by the dynamic chromatin
environment. Epigenetic mechanisms, including covalent modifications to DNA and histone …

[HTML][HTML] Non-coding RNAs as regulators in epigenetics

JW Wei, K Huang, C Yang… - Oncology reports, 2017 - spandidos-publications.com
Epigenetics is a discipline that studies heritable changes in gene expression that do not
involve altering the DNA sequence. Over the past decade, researchers have shown that …