Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …

The basic role of metal ions including copper, zinc and iron in neurological pathologies is
generally accepted. The relationship between the development of disease and particular …

Conspectus The interaction of d-block metal ions (Cu, Zn, Fe, etc.) with intrinsically
disordered proteins (IDPs) has gained interest, partly due to their proposed roles in several …

Metallothioneins (MTs) are a class of ubiquitously occurring low molecular mass, cysteine-
and metal-rich proteins containing sulfur-based metal clusters formed with Zn (II), Cd (II), and …

Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in
numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich …

Alzheimer's disease (AD) is the most prevalent age‐related dementia affecting millions of
people worldwide. Its main pathological hallmark feature is the formation of insoluble protein …

Brain aging is marked by structural, chemical, and genetic changes leading to cognitive
decline and impaired neural functioning. Further, aging itself is also a risk factor for a …

Zinc is more widely used as a cofactor in proteins than any other transition metal ion. In
addition to catalytic and structural functions, zinc (II) ions have a role in information transfer …

The aggregation and accumulation of amyloidogenic peptides and proteins are observed as
pathological features in the brains of patients suffering from neurodegenerative disorders …

Between 5 and 10% of all proteins of a given organism are estimated to require zinc for
function, and hence zinc is essential for almost any given metabolic process. It is therefore of …