Strengths and limitations of in silico tools to assess physicochemical properties, bioactivity, and bioavailability of food-derived peptides

F Rivero-Pino, MC Millan-Linares… - Trends in Food Science …, 2023 - Elsevier
Background Bioactive peptides obtained from different food sources have been proved to
exert several bioactivities, such as antioxidant, antihypertensive, antimicrobial, or anti …

Secreted Aspartyl Proteinases Targeted Multi-Epitope Vaccine Design for Candida dubliniensis Using Immunoinformatics

N Akhtar, JSL Magdaleno, S Ranjan, AK Wani… - Vaccines, 2023 - mdpi.com
Candida dubliniensis is an opportunistic pathogen associated with oral and invasive fungal
infections in immune-compromised individuals. Furthermore, the emergence of C …

Development of multi-epitope vaccines against the monkeypox virus based on envelope proteins using immunoinformatics approaches

C Tan, F Zhu, P Pan, A Wu, C Li - Frontiers in Immunology, 2023 - frontiersin.org
Background Since May 2022, cases of monkeypox, a zoonotic disease caused by the
monkeypox virus (MPXV), have been increasingly reported worldwide. There are, however …

In silico designed mRNA vaccines targeting CA-125 neoantigen in breast and ovarian cancer

L Lu, W Ma, CH Johnson, SA Khan, ML Irwin, L Pusztai - Vaccine, 2023 - Elsevier
Somatic mutation-derived neoantigens are associated with patient survival in breast and
ovarian cancer. These neoantigens are targets for cancer, as shown by the implementation …

Polypharmacological cell-penetrating peptides from venomous marine animals based on immunomodulating, antimicrobial, and anticancer properties

S Hemmati, H Rasekhi Kazerooni - Marine Drugs, 2022 - mdpi.com
Complex pathological diseases, such as cancer, infection, and Alzheimer's, need to be
targeted by multipronged curative. Various omics technologies, with a high rate of data …

MERS virus spike protein HTL-epitopes selection and multi-epitope vaccine design using computational biology

A Joshi, N Akhtar, NR Sharma, V Kaushik… - Journal of …, 2023 - Taylor & Francis
MERS-CoV, a zoonotic virus, poses a serious threat to public health globally. Thus, it is
imperative to develop an effective vaccination strategy for protection against MERS-CoV …

Design of a multi-epitope vaccine against six Nocardia species based on reverse vaccinology combined with immunoinformatics

F Zhu, C Tan, C Li, S Ma, H Wen, H Yang… - Frontiers in …, 2023 - frontiersin.org
Background Nocardia genus, a complex group of species classified to be aerobic
actinomycete, can lead to severe concurrent infection as well as disseminated infection …

A hybrid method for discovering interferon-gamma inducing peptides in human and mouse

A Dhall, S Patiyal, GPS Raghava - Scientific Reports, 2024 - nature.com
Abstract Interferon-gamma (IFN-γ) is a versatile pleiotropic cytokine essential for both innate
and adaptive immune responses. It exhibits both pro-inflammatory and anti-inflammatory …

A web-based method for the identification of IL6-based immunotoxicity in vaccine candidates

A Dhall, S Patiyal, N Sharma, SS Usmani… - Computational Vaccine …, 2023 - Springer
Abstract Interleukin 6 (IL6) is a major pro-inflammatory cytokine that plays a pivotal role in
both innate and adaptive immune responses. In the past, a number of studies reported that …

OPEN ACCESS EDITED BY

PB Fourie, R Pandey, I Viana… - Methods in Vaccines …, 2024 - books.google.com
Avidity of polyclonal antibodies (pAbs) in serum, plasma and mucosal fluids refers to the
overall strength of pAbs-antigen binding and depends on the affinities of pAbs for the …