Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy”

A Trzyna, A Banaś-Ząbczyk - Biomolecules, 2021 - mdpi.com
Adipose-derived stem cells (ASCs) secrete many cytokines, proteins, growth factors, and
extracellular vesicles with beneficial outcomes that can be used in regenerative medicine. It …

Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies

HR Hofer, RS Tuan - Stem cell research & therapy, 2016 - Springer
Adult mesenchymal stem cells (MSCs) represent a subject of intense experimental and
biomedical interest. Recently, trophic activities of MSCs have become the topic of a number …

Strategies to optimize adult stem cell therapy for tissue regeneration

S Liu, J Zhou, X Zhang, Y Liu, J Chen, B Hu… - International journal of …, 2016 - mdpi.com
Stem cell therapy aims to replace damaged or aged cells with healthy functioning cells in
congenital defects, tissue injuries, autoimmune disorders, and neurogenic degenerative …

Secretome from human adipose-derived mesenchymal stem cells promotes blood vessel formation and pericyte coverage in experimental skin repair

BM Silveira, TO Ribeiro, RS Freitas, ACO Carreira… - PLoS …, 2022 - journals.plos.org
Human adipose tissue-derived stem cells (hASC) secretome display various therapeutically
relevant effects in regenerative medicine, such as induction of angiogenesis and tissue …

VEGF promotes endothelial progenitor cell differentiation and vascular repair through connexin 43

L Li, H Liu, C Xu, M Deng, M Song, X Yu, S Xu… - Stem cell research & …, 2017 - Springer
Background Endothelial progenitor cell (EPC) differentiation is considered crucial for
vascular repair. Vascular endothelial growth factor (VEGF) induces EPC differentiation, but …

[HTML][HTML] Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2

MJ Luo, SS Rao, YJ Tan, H Yin, XK Hu, Y Zhang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Healing of the chronic diabetic ulceration and large burns remains a clinical challenge.
Therapeutic fasting has been shown to improve health. Our study tested whether fasting …

Protein biomarkers of cardiac remodeling and inflammation associated with HFpEF and incident events

JA Regan, LK Truby, UA Tahir, DH Katz, M Nguyen… - Scientific reports, 2022 - nature.com
There is increasing evidence that HFpEF is a heterogeneous clinical entity and distinct
molecular pathways may contribute to pathophysiology. Leveraging unbiased proteomics to …

Mass spectrometry analysis of adipose-derived stem cells reveals a significant effect of hypoxia on pathways regulating extracellular matrix

S Riis, A Stensballe, J Emmersen, CP Pennisi… - Stem Cell Research & …, 2016 - Springer
Background Adipose-derived stem cells (ASCs) are being increasingly recognized for their
potential to promote tissue regeneration and wound healing. These effects appear to be …

Harnessing the secretome of adipose-derived stem cells in the treatment of ischemic heart diseases

X Li, T Ma, J Sun, M Shen, X Xue, Y Chen… - Stem cell research & …, 2019 - Springer
Adipose-derived stem cells (ASCs) are promising therapeutic cells for ischemic heart
diseases, due to the ease and efficiency of acquisition, the potential of myocardial lineage …

The origin, progress, and application of cell‐based cardiac regeneration therapy

D Zhuo, I Lei, W Li, L Liu, L Li, J Ni… - Journal of Cellular …, 2023 - Wiley Online Library
Cardiovascular disease (CVD) has become a severe threat to human health, with morbidity
and mortality increasing yearly and gradually becoming younger. When the disease …