Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …

Insights into the role astrocytes and microglia play in normal and diseased brain functioning
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …

Perinatal hypoxia-ischemia resulting in death or lifelong disabilities remains a major clinical
disorder. Neonatal models of hypoxia-ischemia in rodents have enhanced our …

The extracellular concentration of adenosine in the brain increases dramatically during
ischemia. Adenosine A2A receptor is expressed in neurons and glial cells and in …

The steady and dramatic increase in the incidence of Alzheimer's disease (AD) and the lack
of effective treatments have stimulated the search for strategies to prevent or delay its onset …

Ischemic stroke is a complex pathology characterized by a sequence of events that evolve
over time and space. It is the second leading cause of death and the main cause of adult …

Abstract Adenosine A2A receptors (A2ARs) are highly expressed in the human striatum, and
at lower densities in the cerebral cortex, the hippocampus, and cells of the immune system …

This study was designed to investigate whether functional and molecular MRI techniques
are sensitive biomarkers for assessment of neuroinflammation and drug efficacy after …

Ischemia is characterized by a transient, insufficient, or permanent interruption of blood flow
to a tissue, which leads to an inadequate glucose and oxygen supply. The nervous tissue is …