The alterations in myocardial energy substrate metabolism that occur in heart failure, and
the causes and consequences of these abnormalities, are poorly understood. There is …

Myocardial ischemia is one of the main causes of sudden cardiac death, with 80% of victims
suffering from coronary heart disease. In acute myocardial ischemia, the obstruction of …

Changes in neuronal activity create local and transient changes in energy demands at
synapses. Here we discover a metabolic compartment that forms in vivo near synapses to …

Heart failure and cardiovascular disorders represent the leading cause of death in diabetic
patients. Here we present a systematic review of the main mechanisms underlying the …

Chronic anemia is an independent risk factor for mortality in patients with heart failure (HF).
Restoring physiological hemoglobin (Hb) levels is essential to increase oxygen transport …

Over the past several decades there has been increasing research interest in
thermodynamics as applied to biological systems. This concerns topics such as muscle work …

A mathematical model of the whole-body metabolism is developed to predict fuel
homeostasis during exercise by using hormonal control over cellular metabolic processes …

Background Neuro-glial interactions are important for normal functioning of the brain as well
as brain energy metabolism. There are two major working models-in the classical view, both …

The malate–aspartate (M–A) shuttle provides an important mechanism to regulate glycolysis
and lactate metabolism in the heart by transferring reducing equivalents from cytosol into …

When the mechanical work intensity in muscle increases, the elevated ATP consumption
rate must be matched by the rate of ATP production by oxidative phosphorylation in order to …