Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

The limitations of genome-wide association (GWA) studies that focus on the phenotypic
influence of common genetic variants have motivated human geneticists to consider the …

Although whole-genome association studies using tagSNPs are a powerful approach for
detecting common variants, they are underpowered for detecting associations with rare …

Schizophrenia and bipolar disorder are leading causes of morbidity across all populations,
with heritability estimates of∼ 80% indicating a substantial genetic component. Population …

There is strong evidence that rare variants are involved in complex disease etiology. The
first step in implicating rare variants in disease etiology is their identification through …

Production of heat via nonshivering thermogenesis (NST) is critical for temperature
homeostasis in mammals. Uncoupling protein UCP1 plays a central role in NST by …

Motivation To address 'missing heritability'issue, many statistical methods for pathway-based
analyses using rare variants have been proposed to analyze pathways individually …

Abstract ABCA1, ABCG1 transporters, and SR-B1 receptor are the major proteins involved in
cholesterol efflux from cells. We superposed in silico the location of putative cholesterol …

Objective: The present study is on line with our previous studies evaluating the influence of
ATP-binding cassette transporter A1 (ABCA1) gene polymorphisms on the lipid variables of …

Mutations in the ATP-binding cassette transporter A1 (ABCA1) are a major cause of
decreased HDL cholesterol (HDL-C), which infers an increased risk of cardiovascular …