Oxidative stress (OS) is one of the major pathomechanisms of Alzheimer's disease (AD),
which is closely associated with other key events in neurodegeneration such as …

Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …

This paper addresses how long lifespan can be extended via multiple interventions, such as
dietary supplements [eg, curcumin, resveratrol, sulforaphane, complex phytochemical …

Regulation of gene expression by small non-coding RNAs, such as miRNAs and siRNAs, is
an inherent part of complex biological processes that allow function and survival of …

Abstract microRNA-34, a highly conserved microRNA in evolution, is of great interest in
recent years. miR-34 regulates multiple targets and performed many functions in cells, such …

Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has
devastating effects on individuals, often resulting in dementia. AD is primarily defined by the …

Ageing is the biggest risk factor for the development of multiple chronic diseases as well as
increased infection susceptibility and severity of diseases such as influenza and COVID-19 …

Disruption of mitochondrial function is a common feature of inherited mitochondrial diseases
(mitochondriopathies) and many other infectious and non-infectious diseases including viral …

The role of vascular endothelial growth factor (VEGF) in cancer cells is not limited to
angiogenesis; there are also multiple factors, such as neuropilins (non-tyrosine kinases …

Aging, genomic stress, and mitochondrial dysfunction are risk factors for neurodegenerative
pathologies, such as Parkinson disease (PD). Although genomic instability is associated …