In 2020, Beck et al 1 described a novel adult autoinflammatory syndrome entitled VEXAS
(Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic), a newly-discovered disorder …

Abstract VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a
recently described pathological entity. It is an acquired monogenic autoinflammatory …

Summary VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a
pleiotropic, severe autoinflammatory disease caused by somatic mutations in the ubiquitin …

VEXAS (acronym for Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a
fascinating new entity encompassing a variety of clinical manifestations, spanning from auto …

Background VEXAS (vacuoles, E1 enzyme, X-linked, auto-inflammatory, somatic) syndrome
is a newly described auto-inflammatory disease. Many cases feature pulmonary infiltrates or …

To the Editor Somatic mutations in the gene encoding the major E1 ubiquitin ligase, UBA1,
cause VEXAS (Vacuoles, E1-ligase, X-linked, Auto-inflammatory, Somatic), a late-onset …

VEXAS is a newly recognised adult‐onset autoinflammatory syndrome resulting from a
somatic mutation in the UBA1 gene. Herein, we present three cases of VEXAS syndrome in …

Somatic genetic mutations involving the innate and inflammasome signaling are key drivers
of the pathogenesis of myelodysplastic syndromes (MDS). Herein, we present a patient, who …

Patients with rare and complex rheumatic diseases (RDs) present with immense clinical
variability inherent to all immunologic diseases. In addition to systemic and organ‐specific …

Abstract Vacuoles, E1, X-linked, autoimmunity, somatic (VEXAS) syndrome is characterized
by a pathogenic mutation in UBA1, which leads to protean complications including …