Kidney disease is a global health problem with high mortality and socioeconomic burden,
including acute kidney injury (AKI), chronic kidney disease (CKD), diabetic nephropathy …

Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

The renin–angiotensin system (RAS) plays a crucial role in regulating blood pressure and
the cardio-renal system. The classical RAS, mainly mediated by angiotensin I, angiotensin …

SA-AKI is a common condition that can involve disturbances in the RAS, particularly the
canonical angiotensin-converting enzyme (ACE) angiotensin-II (Ang II)/angiotensin II …

Lipopolysaccharide (LPS)-induced acute kidney injury (AKI) is characterized by
inflammation and infiltration of immune cells, mainly neutrophils and macrophages, and …

Dysregulation of the renin–angiotensin–aldosterone-system (RAAS) in sepsis is a complex
and early phenomenon with a likely significant contribution to organ failure and patient …

The article describes the possible pathophysiological origin of COVID-19 and the crucial
role of renin-angiotensin system (RAS), providing several “converging” evidence in support …

A high salt (HS) diet is associated with an increased risk for cardiovascular diseases (CVDs)
and fibrosis is a key contributor to the organ dysfunction involved in CVDs. The activation of …

Acute respiratory distress syndrome (ARDS) is a devastating respiratory disorder,
characterized by overwhelming inflammation in the alveoli without effective pharmacological …

Proteinuria is a risk factor for and consequence of kidney injury. Angiotensin II type 2
receptor (AT2R) is an emerging reno-protective target and is anti-proteinuric under …