Coffee is a widely consumed beverage containing numerous biologically active constituents
predominantly belonging to the polyphenol and alkaloid classes. It has been established …

Major depressive disorder is one of the most common and debilitating psychiatric disorders.
Some of the motivational symptoms of depression, such anergia (lack of self-reported …

Depression is a mental disorder characterized by low mood, lack of motivation, negative
cognitive outlook, and sleep problems. Suicide may occur in severe cases, although suicidal …

Background: The popular drink, coffee (Coffea arabica) is under the great attention of late
because of its promising pharmacological potential. Caffeine (the major constituent of …

Abstract Monoamine oxidase A (MAO-A) is a major enzyme responsible for the deamination
of neurotransmitters such as serotonin (5-HT) in the central nervous system. The decrease in …

Unsatisfactory therapeutic effects of currently used antidepressants force to search for new
pharmacological treatment strategies. Recent research points to the relationship between …

Caffeine is the most widely used behaviorally active drug in the world which exerts its activity
on central nervous system through adenosine receptors. Worrying data indicate that …

Major depressive disorder (MDD) is the foremost cause of global disability, being
responsible for enormous personal, societal, and economical costs. Importantly, existing …

The ketamine's potential for the treatment of refractory depression and anxiety has been
considered one the most important discoveries in the last years, however, repeated use of …

Rationale Depression is a psychiatric disorder that constitutes one of the leading causes of
disability worldwide. 2-Phenyl-3-(phenylselanyl) benzofuran (SeBZF 1) has been studied as …