Recent advances in limb regeneration are revealing the molecular events that integrate
growth control, cell fate programming, and positional information to yield the exquisite …

The axolotl is one of the few tetrapods that are capable of regenerating complicated
biological structures, such as complete limbs, throughout adulthood. Upon injury the axolotl …

In order to contribute to the appropriate tissues during development, cells need to know their
position within the embryo. This positional information is conveyed by gradients of signaling …

Salamanders, such as axolotls and newts, can regenerate complex tissues including entire
limbs. But what mechanisms ensure that an amputated limb regenerates a limb, and not a …

Some organisms, such as the Mexican axolotl, have the capacity to regenerate complicated
biological structures throughout their lives. Which molecular pathways are sufficient to …

Abstract The Mexican Axolotl is one of the few tetrapod species that is capable of
regenerating complete skeletal elements in injured adult limbs. Whether the skeleton (bone …

Introduction: Little is known about how the newly regenerated limb tissues in the Mexican
axolotl seamlessly integrate with the remaining stump tissues to form a functional structure …

Striking similarities between wound healing, epimorphic regeneration and the progression
of solid tumors have been uncovered by recent studies. In this Review, we discuss systemic …

Cellular reprogramming is characterized by the induced dedifferentiation of mature cells into
a more plastic and potent state. This process can occur through artificial reprogramming …

Background The endogenous ability to dedifferentiate, re-pattern, and re-differentiate adult
cells to repair or replace damaged or missing structures is exclusive to only a few tetrapod …