Complement C4, infections, and autoimmune diseases

H Wang, M Liu - Frontiers in immunology, 2021 - frontiersin.org
Complement C4, a key molecule in the complement system that is one of chief constituents
of innate immunity for immediate recognition and elimination of invading microbes, plays an …

Protease allergens as initiators–regulators of allergic inflammation

WT Soh, J Zhang, MD Hollenberg, H Vliagoftis… - Allergy, 2023 - Wiley Online Library
Tremendous progress in the last few years has been made to explain how seemingly
harmless environmental proteins from different origins can induce potent Th2‐biased …

Proteases and protease inhibitors in infectious diseases

AA Agbowuro, WM Huston, AB Gamble… - Medicinal research …, 2018 - Wiley Online Library
There are numerous proteases of pathogenic organisms that are currently targeted for
therapeutic intervention along with many that are seen as potential drug targets. This review …

Immunity to fungi in the lung

LJ Heung, DL Wiesner, K Wang, A Rivera… - Seminars in immunology, 2023 - Elsevier
The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …

Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence

T Heinekamp, A Thywißen, J Macheleidt… - Frontiers in …, 2013 - frontiersin.org
The opportunistic human pathogenic fungus Aspergillus fumigatus produces at least two
types of melanin, namely pyomelanin and dihydroxynaphthalene (DHN) melanin …

Fungal strategies to evade the host immune recognition

MJ Hernández-Chávez, LA Pérez-García… - Journal of Fungi, 2017 - mdpi.com
The recognition of fungal cells by the host immune system is key during the establishment of
a protective anti-fungal response. Even though the immune system has evolved a vast …

Fungal proteases and their pathophysiological effects

I Yike - Mycopathologia, 2011 - Springer
Proteolytic enzymes play an important role in fungal physiology and development. External
digestion of protein substrates by secreted proteases is required for survival and growth of …

[HTML][HTML] Fungal model systems and the elucidation of pathogenicity determinants

E Perez-Nadales, MFA Nogueira, C Baldin… - Fungal genetics and …, 2014 - Elsevier
Fungi have the capacity to cause devastating diseases of both plants and animals, causing
significant harvest losses that threaten food security and human mycoses with high mortality …

Microbial and fungal protease inhibitors—current and potential applications

J Sabotič, J Kos - Applied microbiology and biotechnology, 2012 - Springer
Proteolytic enzymes play essential metabolic and regulatory functions in many biological
processes and also offer a wide range of biotechnological applications. Because of their …

Interference of Aspergillus fumigatus with the immune response

T Heinekamp, H Schmidt, K Lapp, V Pähtz… - Seminars in …, 2015 - Springer
Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent
airborne fungal pathogen of humans. Depending on the host's immune status, the variety of …