Where are the new herbicides?

RY Qu, B He, JF Yang, HY Lin, WC Yang… - Pest Management …, 2021 - Wiley Online Library
Herbicide resistance has become one of the foremost problems in crop production
worldwide. New herbicides are required to manage weeds that have evolved resistance to …

Survey on the recent advances in 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibition by diketone and triketone derivatives and congeneric compounds …

P Governa, G Bernardini, D Braconi… - Journal of Agricultural …, 2022 - ACS Publications
The serendipitous discovery of the HPPD inhibitors from allelopathic plants opened the way
for searching new and effective herbicidal agents by application of classical hit-to-lead …

Integrated Analysis of Metabolome and Transcriptome Reveals Insights for Cold Tolerance in Rapeseed (Brassica napus L.)

A Raza, W Su, MA Hussain, SS Mehmood… - Frontiers in Plant …, 2021 - frontiersin.org
Rapeseed (Brassica napus L.) is an important oilseed crop in the world. Its productivity is
significantly influenced by numerous abiotic stresses, including cold stress (CS) …

A Protocol for Activated Bioorthogonal Fluorescence Labeling and Imaging of 4‐Hydroxyphenylpyruvate Dioxygenase in Plants

X Zeng, X Ma, J Dong, B Li, S Hua Liu, J Yin… - Angewandte …, 2023 - Wiley Online Library
Hydroxyphenylpyruvate dioxygenase (HPPD) plays a crucial role in the synthesis of
nutrients needed to maintain optimal plant growth. Its level is closely linked to the extent of …

Rational redesign of enzyme via the combination of quantum mechanics/molecular mechanics, molecular dynamics, and structural biology study

HY Lin, X Chen, J Dong, JF Yang, H Xiao… - Journal of the …, 2021 - ACS Publications
Increasing demands for efficient and versatile chemical reactions have prompted
innovations in enzyme engineering. A major challenge in engineering α-ketoglutarate …

Design, synthesis, and bioactivity of novel ester-substituted cyclohexenone derivatives as safeners

BW Ye, LX Zhao, ZW Wang, J Shi… - Journal of Agricultural …, 2023 - ACS Publications
Tembotrione, a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor, has been widely
used in many types of plants. Tembotrione has been reported for its likelihood of causing …

Synthesis and herbicidal activity of novel pyrazole aromatic ketone analogs as HPPD inhibitor

Q Fu, PP Cai, L Cheng, LK Zhong… - Pest management …, 2020 - Wiley Online Library
Abstract BACKGROUND 4‐Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13. 11.27)
has been a good target for herbicide discovery. In order to discover novel HPPD herbicides …

[HTML][HTML] Comparison of the binding interactions of 4-hydroxyphenylpyruvate dioxygenase inhibitor herbicides with humic acid: Insights from multispectroscopic …

P Chen, M Shi, X Liu, X Wang, M Fang, Z Guo… - Ecotoxicology and …, 2022 - Elsevier
Hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor is one of the important herbicides to
solve the problem of weed control. With the widespread and continued use of HPPD …

Pharmacophore-oriented discovery of novel 1, 2, 3-benzotriazine-4-one derivatives as potent 4-hydroxyphenylpyruvate dioxygenase inhibitors

YC Yan, W Wu, GY Huang, WC Yang… - Journal of Agricultural …, 2022 - ACS Publications
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a functional protein existing in almost all
aerobic organisms. In the field of agricultural chemicals, HPPD is acknowledged to be one of …

Herbicide metabolism: crop selectivity, bioactivation, weed resistance, and regulation

VK Nandula, DE Riechers, Y Ferhatoglu, M Barrett… - Weed Science, 2019 - cambridge.org
Several grass and broadleaf weed species around the world have evolved multiple-
herbicide resistance at alarmingly increasing rates. Research on the biochemical and …