Cancer cell metastasis is responsible for approximately 90% of deaths related to cancer.
The migration of cancer cells away from the primary tumor and into healthy tissue is driven in …

The compartmentalization of enzymes into organelles is a promising strategy for limiting
metabolic crosstalk and improving pathway efficiency; however, prokaryotes are unicellular …

Abstract CXC chemokine receptor 7 (CXCR7), a novel receptor of CXC motif chemokine
ligand 12 (CXCL12), is associated with the occurrence and metastasis of various malignant …

Solid tumors are inherently difficult to treat because of large regions of hypoxia and are often
chemotherapy-or radiotherapy-resistant. It seems that cancer stem cells reside in hypoxic …

The tissue inhibitor of metalloproteinase-2 (TIMP-2) is originally characterized as an
endogenous inhibitor of matrix metalloproteinases (MMPs) to response collagenolysis …

Display technologies are powerful tools for discovering binding proteins against a broad
range of biological targets. However, it remains challenging to adapt display technologies …

The majority of proteins excreted by human cells and borne at the cell surface are modified
with carbohydrates. Glycoproteins mediate a wide range of processes and adopt …

Matrix metalloproteinases (MMPs) are considered excellent targets for cancer therapy
because of their important roles in multiple aspects of tumor growth and metastatic spread …

Introduction The extracellular matrix (ECM) in the tumor microenvironment contains high
densities of collagen that are highly aligned, resulting in directional migration called contact …

Macromolecular protease inhibitors and camelid single-domain antibodies achieve their
enzymic inhibition functions often through protruded structures that directly interact with …