To replicate their genomes in cells and generate new progeny, viruses typically require
factors provided by the cells that they have infected. Subversion of the cellular machinery …

It has been clear for a number of years that small DNA tumor viruses such as simian virus 40
(SV40) and papillomavirus interact with cell cycle control pathways during lytic replication in …

Resveratrol (3, 5, 4′-trihydroxystilbene) is a natural component of certain foods, such as
grapes, that has been shown to have anti-herpes simplex virus (HSV) activity in vitro. To …

Several observations indicate that late-G1/S-phase-specific cellular functions may be
required for herpes simplex virus (HSV) replication:(i) certain mutant HSV strains are …

Cyclin-dependent kinases (cdks) are required for replication of viruses that replicate only in
dividing cells, such as adeno-and papillomaviruses. Recently, cdks have been shown to be …

Although viral gene expression occurs in the peripheral nervous system during acute
infection, bovine herpesvirus 1 (BHV-1) gene expression is extinguished, many neurons …

In uninfected cells the G2/M transition is regulated by cyclin kinase complex containing cdc2
and, initially, cyclin A, followed by cyclin B. cdc2 is downregulated through phosphorylation …

We have previously shown that two inhibitors specific for cellular cyclin-dependent kinases
(cdks), Roscovitine (Rosco) and Olomoucine (Olo), block the replication of herpes simplex …

Geldanamycin (GA) is an antibiotic targeting the ADP/ATP binding site of heat shock protein
90 (Hsp90). In screening for anti-herpes simplex virus type 1 (HSV-1) candidates, we found …

Although herpes simplex virus (HSV) replicates in noncycling as well as cycling cells,
including terminally differentiated neurons, it has recently been shown that viral replication …