Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and …
MJ Kiel, ÖH Yilmaz, T Iwashita, OH Yilmaz, C Terhorst… - cell, 2005 - cell.com
To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in vivo, we compared the gene expression profiles of highly purified HSCs and non-self …
L Beaugerie, N Brousse, AM Bouvier, JF Colombel… - The Lancet, 2009 - thelancet.com
Background Reports of an increased risk of lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease are controversial. We assessed this …
Sjögren's syndrome (SS) is a prototype autoimmune disease characterized by oral and ocular mucosal dryness following chronic inflammation of salivary and lachrymal glands …
Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells undergo somatic mutation and selection and eventual differentiation into memory B cells or …
T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this …
D Li, W Xiong, Y Wang, J Feng, Y He, J Du… - Science …, 2022 - science.org
The interaction of SIRPα with CD47 represents a major mechanism for preventing macrophage phagocytosis. However, CD47-independent mechanisms are poorly defined …
K Griewank, C Borowski, S Rietdijk, N Wang, A Julien… - Immunity, 2007 - cell.com
Commitment to the T and natural killer T (NKT) cell lineages is determined during αβ T cell receptor (TCR)-mediated interactions of common precursors with ligand-expressing cells in …
G Grütz - Journal of leukocyte biology, 2005 - academic.oup.com
Abstract Interleukin-10 (IL-10) is an important immunomodulatory cytokine, which has attracted much attention because of its anti-inflammatory properties. It reduces antigen …