Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in
Western countries and is considered the hepatic manifestation of metabolic syndrome. The …

Background: An emerging paradigm supports the notion that deregulation of fatty acid
synthase (FASN)-catalyzed de novo FA biogenesis could play a central role in the …

Cellular lipid metabolism has been linked to immune responses; however, the precise
mechanisms by which de novo fatty acid synthesis can regulate inflammatory responses …

The transcription factor carbohydrate-responsive element–binding protein (ChREBP) has
emerged as a central regulator of lipid synthesis in liver because it is required for glucose …

The liver plays a key role in glucose homeostasis, lipid and energy metabolism. Its function
is primarily controlled by the anabolic hormone insulin and its counterparts glucagon …

Non-alcoholic fatty liver disease is tightly associated with insulin resistance, type 2 diabetes
and obesity, but the molecular links between hepatic fat accumulation and insulin resistance …

The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) induces a battery of
cytoprotective genes after oxidative stress. Nrf2 aids in liver regeneration by altering insulin …

Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming a world‐wide public health
problem. NAFLD represents a spectrum of disease ranging from “simple steatosis”, which is …

Patients with nonalcoholic fatty liver disease (NAFLD) are reported to have low growth
hormone (GH) production and/or hepatic GH resistance. GH replacement can resolve the …

Abstract Background/Aims: Glucokinase (GCK) phosphorylates glucose to form glucose 6-
phosphate and thereby regulates hepatic glucose disposal and activates hepatic …