Living cells have evolved over billions of years to develop structural and functional
complexity with numerous intracellular compartments that are formed due to liquid–liquid …

Birth defects are a common occurrence in the United States and worldwide. Currently,
evaluation of potential developmental toxicants (ie, teratogens) relies heavily on animal …

Drug resistance is a leading cause for the failure of cancer treatments. Plasticity of cancer
cells to acquire stem cell-like properties enables them to escape drug toxicity through …

Colonies of induced pluripotent stem cells (iPSCs) reveal aspects of self-organization even
under culture conditions that maintain pluripotency. To investigate the dynamics of this …

The tumor microenvironment (TME) promotes proliferation, drug resistance, and
invasiveness of cancer cells. Therapeutic targeting of the TME is an attractive strategy to …

Stem cell differentiation toward a specific lineage is controlled by its microenvironment.
Polymer scaffolds have long been investigated to provide microenvironment cues; however …

Drug resistance is a major barrier against successful treatments of cancer patients. Gain of
stemness under drug pressure is a major mechanism that renders treatments ineffective …

BACKGROUND Cell‐based high‐throughput platforms using aqueous two‐phase systems
(ATPS) have led to the construction of 3D cultures using ATPS in which stem cells are …

Background The formation of stem cell clones enables close contact of stem cells inside.
The gap junctions in such clone spheres establish a microenvironment that allows frequent …

Cancer cells often adapt to single-agent treatments with chemotherapeutics. Activation of
alternative survival pathways is a major mechanism of drug resistance. A potential approach …