Aging is characterized by several physiological changes in the human body, such as the
remodeling/redistribution of body fat, highlighted by the increase in fat in the abdominal …

The purpose of this Perspective is to propose a new, collaborative paradigm to study
cognitive aging. The field of cognitive aging from the neuroscience perspective has focused …

Brown adipose tissue (BAT) is of great importance in rodents for maintaining their core
temperature via non-shivering thermogenesis in the mitochondria. BAT′ s thermogenic …

Background Animal models of spontaneous osteoarthritis (OA) are sparse and not well
characterized. The purpose of the present study is to examine OA-related changes and …

The Notch signaling pathway is crucial for skeletal muscle development, regeneration,
inflammation, and aging. This study investigated the association between interleukin-10 (IL …

Age-related cognitive decline and disruptions in circadian rhythms are growing problems as
the average human life span increases. Multiple strains of the senescence-accelerated …

The liver is sensitive to aging because the risk of hepatopathy, including fatty liver, hepatitis,
fibrosis, cirrhosis, and hepatocellular carcinoma, increases dramatically with age. Long non …

Senescence impairs liver physiology, mitochondrial function and circadian regulation,
resulting in systemic metabolic dysregulation. Given the limited research on the effects of …

Cardiac circadian rhythms are an important regulator of body functions, including cardiac
activities and blood pressure. Disturbance of circadian rhythm is known to trigger and …