Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …

Insulin exists in the central nervous system, where it executes two important functions in the
hypothalamus: the suppression of food intake and the improvement of glucose metabolism …

Leukemia cells in the bone marrow must meet the biochemical demands of increased cell
proliferation and also survive by continually adapting to fluctuations in nutrient and oxygen …

The Wnt coreceptors Lrp5 and Lrp6 are essential for normal postnatal bone accrual and
osteoblast function. In this study, we identify a previously unrecognized skeletal function …

Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal
pathways in control of energy and glucose homeostasis. However, the specific ceramide …

Hypertriglyceridemia is the most common lipid disorder in obesity and type 2 diabetes. It
results from increased production and/or decreased clearance of triglyceride-rich …

Chronic endoplasmic reticulum (ER) stress and sustained activation of unfolded protein
response (UPR) signaling contribute to the development of type 2 diabetes in obesity. UPR …

Overweight and obesity pose significant health problems globally, and are causatively
linked to metabolic dysregulation. The hypothalamus integrates neural, nutritional, and …

Numerous environmental, physiological, and pathological insults disrupt protein-folding
homeostasis in the endoplasmic reticulum (ER), referred to as ER stress. Eukaryotic cells …

Endoplasmic reticulum (ER) is a crucial single membrane organelle that acts as a quality
control system for cellular proteins as it is intricately involved in their synthesis, folding and …