Caffeic acid belongs to the polyphenol compounds we consume daily, often in the form of
coffee. Even though it is less explored than caffeic acid phenethyl ester, it still has many …

Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …

Alzheimer's disease, a major and increasing global health challenge, is an irreversible,
progressive form of dementia, associated with an ongoing decline of brain functioning. The …

Sulfonamide derivatives are frequently seen structural motifs in medicinal chemistry. Almost
a century after Gerhard Domagk's pioneering work leading to the first sulfonamide antibiotic …

Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …

Abstract 'Indane′ and its analogues indene, 1‐indenone, and 1, 3‐indandione present an
attractive biological profile for the rational development of therapeutic molecules. The …

Drug development efforts that focused on single targets failed to provide effective treatment
for Alzheimer's disease (AD). Therefore, we designed cholinesterase inhibition (ChEI) …

A series of multitarget-directed ligands (MTDLs) was designed by functionalizing a pseudo-
irreversible butyrylcholinesterase (BChE) inhibitor. The obtained hybrids were investigated …

On the basis of our previous work, a novel series of (4-(1, 2, 4-oxadiazol-5-yl) phenyl)-2-
aminoacetamide derivatives were synthesized and evaluated as multifunctional ligands for …

The neuroprotective potential of 32 natural extracts obtained from olive oil by-products was
investigated. The online coupling of supercritical fluid extraction (SFE) and dynamic …