Common changes in rat cortical gene expression after valproate or lithium treatment particularly affect pre-and post-synaptic pathways that regulate four …

B Dean, E Scarr - The World Journal of Biological Psychiatry, 2024 - Taylor & Francis
Objectives We have postulated that common changes in gene expression after treatment
with different therapeutic classes of psychotropic drugs contribute to their common …

The Genomic Intersection of Oligodendrocyte Dynamics in Schizophrenia and Aging Unravels Novel Pathological Mechanisms and Therapeutic Potentials

AD Rivera, JR Normanton, AM Butt, K Azim - International Journal of …, 2024 - mdpi.com
Schizophrenia is a significant worldwide health concern, affecting over 20 million individuals
and contributing to a potential reduction in life expectancy by up to 14.5 years. Despite its …

Molecular overlaps of neurological manifestations of COVID-19 and schizophrenia from a proteomic perspective

ASLM Antunes, G Reis-de-Oliveira… - European Archives of …, 2024 - Springer
COVID-19, a complex multisystem disorder affecting the central nervous system, can also
have psychiatric sequelae. In addition, clinical evidence indicates that a diagnosis of a …

[HTML][HTML] Small nucleolar RNAs and the brain: Growing evidence supporting their role in psychiatric disorders.

J Salles, R Lin, G Turecki - Biological Psychiatry Global Open Science, 2024 - Elsevier
Non-coding RNAs comprise the majority of the transcriptome and represent an emerging
area of research. Among them, small nucleolar RNAs (snoRNAs) have emerged as a …

Advancing Mental Health Research Through Strategic Integration of Transdiagnostic Dimensions and Genomics

AE Doyle, CE Bearden, RE Gur, DH Ledbetter… - Biological …, 2024 - Elsevier
Genome wide studies are yielding a growing catalogue of common and rare variants that
confer risk for psychopathology. Yet, despite representing unprecedented progress …

Analysis of single-cell transcriptome data from a mouse model implicates protein synthesis dysfunction in schizophrenia

AE Weller, TN Ferraro, GA Doyle, BC Reiner… - Genes & Genomics, 2024 - Springer
Background Schizophrenia is a mental disorder that causes considerable morbidity, whose
risk largely results from genetic factors. Setd1a is a gene implicated in schizophrenia …

[PDF][PDF] 单细胞转录组技术在神经退行性疾病上的应用研究进展

邬建飞, 刘宇, 魏岱旭, 蒲建林, 蔡端芳… - 中国比较医学 …, 2023 - zgbjyx.cnjournals.com
单细胞转录组技术在神经退行性疾病上的应用研究进展 Page 1 2023 年12 月 第33 卷第12 期
中国比较医学杂志 CHINESE JOURNAL OF COMPARATIVE MEDICINE December, 2023 Vol …

Astrocyte-Neuron Interactions in Substance Use Disorders

EV Harder, JP Franklin, JW VanRyzin… - … -Neuron Interactions in …, 2024 - Springer
Engagement of astrocytes within the brain's reward circuitry has been apparent for
approximately 30 years, when noncontingent drug administration was observed to lead to …

FKBP51 in a dynamic environment

L van Doeselaar - 2023 - pure.mpg.de
Mental health disorders are a pressing global health-threat, affecting millions of people
world-wide, which has already cost the world economy over 2.5 trillion dollars, making it a …

FKBP51 in a dynamic environment

L Doeselaar - 2023 - edoc.ub.uni-muenchen.de
Mental health disorders are a pressing global health-threat, affecting millions of people
world-wide, which has already cost the world economy over 2.5 trillion dollars, making it a …