PPARs and microbiota in skeletal muscle health and wasting

R Manickam, K Duszka, W Wahli - International journal of molecular …, 2020 - mdpi.com
Skeletal muscle is a major metabolic organ that uses mostly glucose and lipids for energy
production and has the capacity to remodel itself in response to exercise and fasting …

Physiological functions of peroxisome proliferator-activated receptor β

JG Neels, PA Grimaldi - Physiological reviews, 2014 - journals.physiology.org
The peroxisome proliferator-activated receptors, PPARα, PPARβ, and PPARγ, are a family of
transcription factors activated by a diversity of molecules including fatty acids and fatty acid …

Metabolic and inflammatory adaptation of reactive astrocytes: role of PPARs

J Iglesias, L Morales, GE Barreto - Molecular neurobiology, 2017 - Springer
Astrocyte-mediated inflammation is associated with degenerative pathologies such as
Alzheimer's and Parkinson's diseases and multiple sclerosis. The acute inflammation and …

The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2

Z Gan, EM Burkart-Hartman, DH Han… - Genes & …, 2011 - genesdev.cshlp.org
To identify new gene regulatory pathways controlling skeletal muscle energy metabolism,
comparative studies were conducted on muscle-specific transgenic mouse lines expressing …

PPARβ/δ: linking metabolism to regeneration

A Magadum, FB Engel - International Journal of Molecular Sciences, 2018 - mdpi.com
In contrast to the general belief that regeneration is a rare event, mainly occurring in simple
organisms, the ability of regeneration is widely distributed in the animal kingdom. Yet, the …

Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARα) and its lipid ligands

M Fidaleo, F Fanelli, M Paola Ceru… - Current medicinal …, 2014 - ingentaconnect.com
Signalling lipids are known to control a wide array of cellular processes, including cell
proliferation, apoptosis, migration, and energy metabolism. Fatty acids and their derivatives …

The circadian clock, metabolism and obesity

U Albrecht - Obesity Reviews, 2017 - Wiley Online Library
In the last decades, obesity has been on the rise becoming a burden for health care
systems. The reasons behind this rise are most likely caused by lifestyle rather than by an …

Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids

JPV Heuvel - Progress in molecular biology and translational …, 2012 - Elsevier
Diets rich in ω3 polyunsaturated fatty acids (ω3-PUFAs) such as alpha-linolenic acid,
eicosapentaenoic acid, and docosahexaenoic acid are associated with decreased …

Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion

T Adhikary, DT Brandt, K Kaddatz, J Stockert, S Naruhn… - Oncogene, 2013 - nature.com
Besides its established functions in intermediary metabolism and developmental processes,
the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) has a less …

Skin phototype: a new perspective

V Maresca, E Flori, M Picardo - Pigment cell & melanoma …, 2015 - Wiley Online Library
Cutaneous phototype is considered mainly related to cutaneous pigmentation and to the
eumelanin/pheomelanin ratio, which is mostly genetically determined by the melanocortin 1 …