Large animal models for stem cell therapy

J Harding, RM Roberts, O Mirochnitchenko - Stem cell research & therapy, 2013 - Springer
The field of regenerative medicine is approaching translation to clinical practice, and
significant safety concerns and knowledge gaps have become clear as clinical practitioners …

Cracking the egg: potential of the developing chicken as a model system for nonclinical safety studies of pharmaceuticals

S Bjørnstad, LPE Austdal, B Roald, JC Glover… - … of Pharmacology and …, 2015 - ASPET
The advance of perinatal medicine has improved the survival of extremely premature
babies, thereby creating a new and heterogeneous patient group with limited information on …

[HTML][HTML] Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury

C Nicaise, D Mitrecic, A Falnikar… - World journal of stem …, 2015 - ncbi.nlm.nih.gov
Neglected for years, astrocytes are now recognized to fulfill and support many, if not all,
homeostatic functions of the healthy central nervous system (CNS). During …

Immunohistochemical toolkit for tracking and quantifying xenotransplanted human stem cells

J Allard, K Li, XM Lopez, S Blanchard… - Regenerative …, 2014 - Taylor & Francis
Aim: Biomarker-based tracking of human stem cells xenotransplanted into animal models is
crucial for studying their fate in the field of cell therapy or tumor xenografting. Materials & …

Selective removal of undifferentiated human embryonic stem cells using magnetic activated cell sorting followed by a cytotoxic antibody

K Schriebl, G Satianegara, A Hwang… - … Engineering Part A, 2012 - liebertpub.com
One of the most pertinent concerns of using differentiated cells derived from human
embryonic stem cells (hESC) is the presence of residual undifferentiated hESC, because …

Transplantation of neural stem cells derived from human cord blood to the brain of adult and neonatal rats

A Jablonska, H Kozlowska, I Markiewicz… - Acta neurobiologiae …, 2010 - ane.pl
Searching for a reliable source of alternative neural stem cells for experimental treatment of
neurological disorders we have established neural stem cell line derived from human …

Xenotransplantation of human stem cells into the chicken embryo

JL Boulland, G Halasi, N Kasumacic… - JoVE (Journal of …, 2010 - jove.com
The chicken embryo is a classical animal model for studying normal embryonic and fetal
development and for xenotransplantation experiments to study the behavior of cells in a …

Human umbilical cord blood-derived mesenchymal stem cells promote regeneration of crush-injured rat sciatic nerves★

MA Sung, HJ Jung, JW Lee, JY Lee… - Neural Regeneration …, 2012 - journals.lww.com
Several studies have demonstrated that human umbilical cord blood-derived mesenchymal
stem cells can promote neural regeneration following brain injury. However, the therapeutic …

Nonviral minicircle generation of induced pluripotent stem cells compatible with production of chimeric chickens

P Yu, Y Lu, BJ Jordan, Y Liu, JY Yang… - … " Cloning and Stem …, 2014 - liebertpub.com
Chickens are vitally important in numerous countries as a primary food source and a major
component of economic development. Efforts have been made to produce transgenic birds …

Interordinal chimera formation between medaka and zebrafish for analyzing stem cell differentiation

N Hong, S Chen, R Ge, J Song, M Yi… - Stem cells and …, 2012 - liebertpub.com
Chimera formation is a standard test for pluripotency of stem cells in vivo. Interspecific
chimera formation between distantly related organisms offers also an attractive approach for …