In the last century, molecular crystals functioned predominantly as a means for determining
the molecular structures via X-ray diffraction, albeit as the century came to a close the …

The concept of materials science tetrahedron (MST) concisely depicts the inter-dependent
relationship among the structure, properties, performance, and processing of a drug. Similar …

Nanoindentation is a technique for measuring the elastic modulus and hardness of small
amounts of materials. This method, which has been used extensively for characterizing …

We present an overview of very recent advances in the understanding of structure–
mechanical property correlations in molecular crystals. After the introductory part on some …

Despite the ability to characterize the plasticity of powders in a material-sparing and
expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to …

We report here the first pharmaceutical twistable hydrogen-bonded two-dimensional plastic
hydrate crystal of a well-known psychoactive drug, caffeine (CAH). The availability of two …

Mechanical properties of pharmaceutical materials, eg, Young's modulus (E), indentation
hardness (H), and tensile strength (σ t), play an important role in powder compaction …

Crystals of voriconazole, an antifungal drug, are soft in nature, and this is disadvantageous
during compaction studies where pressure is applied on the solid. Crystal engineering is …

The current emphasis of crystal engineering, which has evolved over the past three decades
through crystal packing analysis and identification of crystal design strategies, has shifted …

Mechanical behavior of pharmaceutical crystals directly impacts the formulation
development and manufacturing of drug products. The understanding of crystal structure …