Pharmacology and emerging therapies for group 3 pulmonary hypertension due to chronic lung disease

J Gonzales, DR Fraidenburg - Pharmaceuticals, 2023 - mdpi.com
Pulmonary hypertension (PH) frequently complicates chronic lung disease and is associated
with high morbidity and poor outcomes. Individuals with interstitial lung disease and chronic …

[HTML][HTML] Loss of JCAD/KIAA1462 Protects the Lung from Acute and Chronic Consequences of Chronic Obstructive Pulmonary Disease

R Suraya, T Nagano, M Yumura, T Hara… - International Journal of …, 2024 - mdpi.com
Even with recent advances in pathobiology and treatment options, chronic obstructive
pulmonary disease (COPD) remains a major contributor to morbidity and mortality. To …

[HTML][HTML] Am80-Encapsulated Lipid Nanoparticles, Developed with the Aim of Achieving Alveolar Regeneration, Have an Improvement Effect on Pulmonary …

T Akita, Y Morita, T Kawai, K Oda, K Tange, Y Nakai… - Pharmaceutics, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis and
emphysema, and current drug treatments target its symptoms. Thus, the development of a …

NF‐κB affected the serum levels of TNF‐α and IL‐1β via activation of the MAPK/NF‐κB signaling pathway in rat model of acute pulmonary microthromboembolism

Y Zhong, B Liang, X Zhang, J Li, D Zeng… - Pulmonary …, 2024 - Wiley Online Library
Pulmonary thromboembolism caused by thrombi blocking major pulmonary artery and its
branches, is a frequently encountered phenomenon and an important cause of high …

[HTML][HTML] Acute Amelioration of Inflammatory Activity Caused by Endothelin-2 Deficiency during Acute Lung Injury

A Musthafa, GRT Ryanto, R Suraya… - Kobe Journal of …, 2023 - ncbi.nlm.nih.gov
In acute lung injury (ALI), a severe insult induces a hyperinflammatory state in the lungs. The
mortality rate of severe ALI remains high, and novel mechanistic insights are required to …