Overview of antagonists used for determining the mechanisms of action employed by potential vasodilators with their suggested signaling pathways

YC Loh, CS Tan, YS Ch'ng, M Ahmad, MZ Asmawi… - Molecules, 2016 - mdpi.com
This paper is a review on the types of antagonists and the signaling mechanism pathways
that have been used to determine the mechanisms of action employed for vasodilation by …

Perivascular adipose tissue, inflammation and vascular dysfunction in obesity

J Van de Voorde, C Boydens… - Current vascular …, 2014 - ingentaconnect.com
Adipocytes are no longer considered just as cells related to storage of energy and
thermoregulation. Now we know that they release a huge number of paracrine and …

Adipose tissue as regulator of vascular tone

C Boydens, N Maenhaut, B Pauwels… - Current hypertension …, 2012 - Springer
Adipokines secreted by visceral, subcutaneous, and perivascular adipocytes are involved in
the regulation of vascular tone by acting as circulatory hormones (leptin, adiponectin …

NaHS induces relaxation response in prostaglandin F2α precontracted bovine retinal arteries partially via Kv and Kir channels

S Takır, GZ Ortaköylü, A Toprak… - Experimental Eye …, 2015 - Elsevier
Hydrogen sulphide (H 2 S) is known to be produced endogenously in ocular tissues with the
highest levels in the retina and cornea. However, it is yet unclear whether it can modulate …

Constriction of porcine retinal arterioles induced by endothelin‐1 and the thromboxane analogue U46619 in vitro decreases with increasing vascular branching level

MS Torring, C Aalkjaer, T Bek - Acta Ophthalmologica, 2014 - Wiley Online Library
Purpose: The retinal blood flow depends on the diameter of retinal arterioles, but diameter
changes in these vessels have hitherto only been assessed in vessels larger than …

The role of fatty acids in the regulation of cerebral vascular function and neuroprotection in ischemia

HW Lin, M Perez-Pinzon - CNS & Neurological Disorders-Drug …, 2013 - ingentaconnect.com
Cerebral circulation is tightly regulated by vasoactive substances. There is a delicate
balance among vasoconstriction and vasodilation factors. During ischemia/stroke, cerebral …

Retina derived relaxation is mediated by Kir channels and the inhibition of Ca2+ sensitization in isolated bovine retinal arteries

S Takır, BS Uydeş-Doğan, O Özdemir - Experimental Eye Research, 2015 - Elsevier
Retinal relaxing factor (RRF) has recently been identified as a novel paracrine regulator of
retinal circulation acting differently from well known mediators of the endothelium and the …

Neuropeptide Y treatment induces retinal vasoconstriction and causes functional and histological retinal damage in a porcine ischaemia model

AT Christiansen, NB Sørensen, KA Haanes… - Acta …, 2018 - Wiley Online Library
Purpose To investigate the effects of intravitreal neuropeptide Y (NPY) treatment following
acute retinal ischaemia in an in vivo porcine model. In addition, we evaluated the …

The elevation of intraocular pressure is associated with apoptosis and increased immunoreactivity for nitric oxide synthase in rat retina whereas the effectiveness of …

S Takır, E Gürel-Gürevin, A Toprak… - Experimental Eye …, 2016 - Elsevier
Glaucoma is a progressive ocular disease that stands in the upper rank for the cause of
blindness in worldwide. In the present study, we aimed to elucidate the possible …

Hydrogen sulfide dilates the isolated retinal artery mainly via the activation of myosin phosphatase

AT Semiz, AB Teker, K Yapar, BSU Doğan, S Takır - Life Sciences, 2020 - Elsevier
Abstract Aims Hydrogen sulfide (H 2 S) is shown in ocular tissues and suggested to involve
in the regulation of retinal circulation. However, the mechanism of H 2 S-induced relaxation …