Simple Summary MMP9, due to its proteolytic activity, plays a key role in tumorigenesis by
regulating migration, epithelial-to-mesenchymal transition and survival of cancer cells …

The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three
decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs …

This review aims to provide an overview of recent developments regarding the roles of
MMPs in tumour invasion and metastasis. Much of the mortality burden belonging to cancer …

Abstract Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are
collectively known as gelatinases whereas MMP-2 is gelatinase-A and MMP-9 is termed as …

Angiogenesis is facilitated by the proteolytic activities of members of the matrix
metalloproteinase (MMP) family. More specifically, MMP-9 and MT1-MMP directly regulate …

Although matrix metalloproteinases (MMPs) are implicated in the regulation of numerous
physiological processes, evidence of their pathological roles have also been obtained in the …

This account exemplifies our recent progress on the strategic incorporation of fluorine and
organofluorine groups to (i) taxoid anticancer agents,(ii) acylhydrazone-based antifungal …

The initiation of atherosclerosis (AS) induced by dyslipidemia is accompanied by endothelial
dysfunction, including decreased healing ability and increased recruitment of monocytes …

Matrix metalloproteinase9 (MMP9) is known to be highly expressed during metastatic cancer
where most known potential inhibitors failed in the clinical trials. This study aims to select …

Simple Summary Cell surface proteases (so-called ectoproteases) are associated with
cancer, and their targeting may confer valuable options for the improvement of cancer …