The protease renin is the key enzyme of the renin-angiotensin-aldosterone cascade, which
is relevant under both physiological and pathophysiological settings. The kidney is the only …

Cyclooxygenase-derived prostanoids exert complex and diverse functions within the kidney.
The biological effect of each prostanoid is controlled at multiple levels, including (a) …

Background: Sodium glucose cotransporter 2 inhibitors may reduce kidney hyperfiltration,
thereby preventing diabetic kidney disease progression, which may in turn reduce …

The volume of extracellular fluid (ECF) is maintained within narrow limits in normal human
subjects, despite day-to-day variations in dietary intake of salt and water over a wide range …

Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors
that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital …

Gambaro G, Perazella MA (Division of Nephrology, University Hospital, Padua, Italy; and
Section of Nephrology, Yale University, New Haven, CT, USA). Adverse renal effects of anti …

Although nonsteroidal anti-inflammatory drugs (NSAIDs) effectively treat a variety of
inflammatory diseases, these agents may cause deleterious effects on kidney function …

The kidney plays a central role in the regulation of arterial blood pressure. A large body of
experimental and physiological evidence indicates that renal control of extracellular volume …

In adult mammalian kidney, cyclooxygenase-2 (COX-2) expression is found in a restricted
subpopulation of cells. The two sites of renal COX-2 localization detected in all species to …

Medications cause renal failure through a variety of mechanisms. Hemodynamic renal
failure may result from drugs that reduce renal prostaglandins and hence renal blood flow …