Axonal regeneration: underlying molecular mechanisms and potential therapeutic targets

R Akram, H Anwar, MS Javed, A Rasul, A Imran… - Biomedicines, 2022 - mdpi.com
Axons in the peripheral nervous system have the ability to repair themselves after damage,
whereas axons in the central nervous system are unable to do so. A common and important …

Modulation of the crosstalk between Schwann cells and macrophages for nerve regeneration: a therapeutic strategy based on a multifunctional tetrahedral framework …

J Li, Y Yao, Y Wang, J Xu, D Zhao, M Liu… - Advanced …, 2022 - Wiley Online Library
Peripheral nerve injury (PNI) is currently recognized as one of the most significant public
health issues and affects the general well‐being of millions of individuals worldwide …

[HTML][HTML] Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets

G Tezel - Progress in retinal and eye research, 2022 - Elsevier
Neuroinflammation relying on the inflammatory responses of glial cells has emerged as an
impactful component of the multifactorial etiology of neurodegeneration in glaucoma. It has …

Radial glia and radial glia-like cells: Their role in neurogenesis and regeneration

Y Miranda-Negrón, JE García-Arrarás - Frontiers in Neuroscience, 2022 - frontiersin.org
Radial glia is a cell type traditionally associated with the developing nervous system,
particularly with the formation of cortical layers in the mammalian brain. Nonetheless, some …

Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons

D Halawani, Y Wang, A Ramakrishnan, M Estill… - Nature …, 2023 - nature.com
Axon regeneration of dorsal root ganglia (DRG) neurons after peripheral axotomy involves
reconfiguration of gene regulatory circuits to establish regenerative gene programs …

Interaction between Schwann cells and other cells during repair of peripheral nerve injury

WR Qu, Z Zhu, J Liu, DB Song, H Tian… - Neural regeneration …, 2021 - journals.lww.com
Peripheral nerve injury (PNI) is common and, unlike damage to the central nervous system
injured nerves can effectively regenerate depending on the location and severity of injury …

Emerging role of HDACs in regeneration and ageing in the peripheral nervous system: repair Schwann cells as pivotal targets

JA Gomez-Sanchez, N Patel, F Martirena… - International Journal of …, 2022 - mdpi.com
The peripheral nervous system (PNS) has a remarkable regenerative capacity in
comparison to the central nervous system (CNS), a phenomenon that is impaired during …

Calcitonin gene‐related peptide induces the histone H3 lysine 9 acetylation in astrocytes associated with neuroinflammation in rats with neuropathic pain

C Sun, Q An, R Li, S Chen, X Gu, S An… - CNS Neuroscience & …, 2021 - Wiley Online Library
Aims Calcitonin gene‐related peptide (CGRP) as a regulator of astrocyte activation may
facilitate spinal nociceptive processing. Histone H3 lysine 9 acetylation (H3K9ac) is …

Intra-axonal mechanisms driving axon regeneration

TP Smith, PK Sahoo, AN Kar, JL Twiss - Brain research, 2020 - Elsevier
Traumatic injury to the peripheral and central nervous systems very often causes axotomy,
where an axon loses connections with its target resulting in loss of function. The axon …

Exercise ameliorates spinal cord injury by changing DNA methylation

G Davaa, JY Hong, TU Kim, SJ Lee, SY Kim, K Hong… - Cells, 2021 - mdpi.com
Exercise training is a traditional method to maximize remaining function in patients with
spinal cord injury (SCI), but the exact mechanism by which exercise promotes recovery after …